Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.40 |
| ▸ | RXRB | P28702 | 1/20 | 0.40 |
| ▸ | RXRG | P48443 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12366505 | 0.92 | CNR2 (0.39) | CNR2KDM4EKMT2ADCTPP1CNR1 | |
| SCHEMBL12366238 | 0.90 | DCTPP1 (0.42) | RXRACNR2KDM4EALDH1A1DCTPP1 | |
| SCHEMBL12366212 | 0.90 | CNR1 (0.44) | RXRAKDM4EALDH1A1RECQLSMN1; SMN2 | |
| SCHEMBL12366308 | 0.88 | RXRA (0.43) | RXRAKDM4EALDH1A1USP2MAPT | |
| SCHEMBL12366275 | 0.88 | CFTR (0.42) | RXRAKDM4EDCTPP1CNR1HPGD | |
| SCHEMBL12366320 | 0.88 | KDM4E (0.47) | RXRACNR2KDM4EALDH1A1MEN1 | |
| SCHEMBL12366245 | 0.87 | CNR1 (0.43) | RXRACNR2KDM4EALDH1A1MEN1 | |
| SCHEMBL12366313 | 0.87 | CNR1 (0.38) | RXRAMAPK8KDM4EALDH1A1MEN1 | |
| SCHEMBL12366324 | 0.85 | NR1H2 (0.49) | RXRAKDM4EMEN1KMT2ADCTPP1 | |
| SCHEMBL12366395 | 0.85 | CCR2 (0.44) | KDM4EDCTPP1CNR1HPGDITGB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7998986-B2 | Heterocyclic compounds, in particular N-substituted pyridones for modulating the activity of nuclear receptors | EXELIXIS PATENT COMPANY LLC (US) | 2011-08-16 | — | — | US | disclosed |