Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKN1 | Q16512 | 1/20 | 0.43 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.38 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.38 |
| ▸ | CFTR | P13569 | 1/20 | 0.36 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | CDC7 | O00311 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | CLPP | Q16740 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12366212 | 0.92 | CNR1 (0.44) | PKN1PKN2CNR1DCTPP1CFTR | |
| SCHEMBL12366275 | 0.90 | CFTR (0.42) | CNR1DCTPP1CFTRRXRANR1H2 | |
| SCHEMBL12366238 | 0.90 | DCTPP1 (0.42) | CNR1DCTPP1CFTRRXRANR1H2 | |
| SCHEMBL12366364 | 0.89 | GRIN1 (0.39) | PKN1PKN2GRIN1GRIN2BHPGD | |
| SCHEMBL12366351 | 0.88 | AR (0.43) | GRIN1GRIN2B | |
| SCHEMBL12366320 | 0.88 | KDM4E (0.47) | CNR1DCTPP1RXRANR1H2NR1H3 | |
| SCHEMBL12366308 | 0.88 | RXRA (0.43) | CNR1DCTPP1RXRANR1H2NR1H3 | |
| SCHEMBL12366313 | 0.87 | CNR1 (0.38) | CNR1DCTPP1CFTRRXRANR1H2 | |
| SCHEMBL12366245 | 0.87 | CNR1 (0.43) | CNR1DCTPP1RXRANR1H2NR1H3 | |
| SCHEMBL12366395 | 0.85 | CCR2 (0.44) | CNR1DCTPP1HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7998986-B2 | Heterocyclic compounds, in particular N-substituted pyridones for modulating the activity of nuclear receptors | EXELIXIS PATENT COMPANY LLC (US) | 2011-08-16 | — | — | US | disclosed |