SCHEMBL12422807

SCHEMBL12422807

COc1ccc(CN(C=C(c2ccccc2)c2ccccc2)Cc2ccc(OC)cc2)cc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACHE P22303 1/20 0.51
MEN1 O00255 2/20 0.48
KMT2A Q03164 2/20 0.48
LTA4H P09960 1/20 0.47
TDP1 Q9NUW8 3/20 0.46
TAS2R14 Q9NYV8 2/20 0.46
ALDH1A1 P00352 2/20 0.46
ALOX12 P18054 1/20 0.46
HTT P42858 1/20 0.46
NPSR1 Q6W5P4 1/20 0.46
GPR55 Q9Y2T6 1/20 0.46
L3MBTL1 Q9Y468 1/20 0.46
OPRM1 P35372 1/20 0.46
OPRL1 P41146 1/20 0.46
G6PC1 P35575 1/20 0.46
PTGES O14684 1/20 0.45
TAS2R8 Q9NYW2 1/20 0.45
CXCR3 P49682 1/20 0.45
CES2 O00748 1/20 0.45
CES1 P23141 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12422886 0.98 ACHE (0.54) ACHEMEN1KMT2ALTA4HTDP1
SCHEMBL12422791 0.83 G6PC1 (0.43) MEN1KMT2AALDH1A1G6PC1TSHR
SCHEMBL12422802 0.82 CYP2C19 (0.44) MEN1KMT2ATAS2R14G6PC1CES2
SCHEMBL12422811 0.79 L3MBTL1 (0.46) MEN1KMT2ATDP1TAS2R14ALDH1A1
SCHEMBL12422818 0.76 PDPK1 (0.44) ACHEPTGESCYP1A2CYP3A4CYP2D6
SCHEMBL12422835 0.76 CYP2C19 (0.49) MEN1KMT2ATAS2R14ALDH1A1CES2
SCHEMBL12422840 0.75 KMT2A (0.38) MEN1KMT2AALDH1A1G6PC1CYP2C19
SCHEMBL13580064 0.74 KDM4E (0.47) KMT2ALTA4HALDH1A1CES2CES1
SCHEMBL12422795 0.74 ALDH1A1 (0.40) MEN1KMT2AALDH1A1NPSR1CES2
SCHEMBL3278635 0.73 TRPA1 (0.58) ACHEMEN1KMT2ALTA4HTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7977020-B2 Electrophotographic photoreceptor containing enamine compound, image formation apparatus provided with the same, enamine compound and method for producing the same SHARP KABUSHIKI KAISHA (JP) 2011-07-12 US disclosed
US-7977020-B2 Electrophotographic photoreceptor containing enamine compound, image formation apparatus provided with the same, enamine compound and method for producing the same SHARP KABUSHIKI KAISHA (JP) 2011-07-12 US disclosed
US-20080286671-A1 Electrophotographic photoreceptor containing enamine compound, image formation apparatus provided with the same, enamine compound and method for producing the same SHARP KABUSHIKI KAISHA (JP) 2008-11-20 US disclosed
US-20080286671-A1 Electrophotographic photoreceptor containing enamine compound, image formation apparatus provided with the same, enamine compound and method for producing the same SHARP KABUSHIKI KAISHA (JP) 2008-11-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080286671-A1 Electrophotographic photoreceptor containing enamine compound, image formation apparatus provided with the same, enamine compound and method for producing the same SLC1A2, SLC1A1, SLC18A1 ACHE 2034/4885MEN1 1117/4885KMT2A 1002/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.