Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 10/20 | 0.78 |
| ▸ | HTR2A | P28223 | 10/20 | 0.78 |
| ▸ | DRD3 | P35462 | 3/20 | 0.78 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.78 |
| ▸ | HTR2C | P28335 | 3/20 | 0.78 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.78 |
| ▸ | HRH1 | P35367 | 3/20 | 0.78 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.78 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.78 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.78 |
| ▸ | DRD1 | P21728 | 2/20 | 0.78 |
| ▸ | DRD4 | P21917 | 2/20 | 0.78 |
| ▸ | DRD5 | P21918 | 2/20 | 0.78 |
| ▸ | HTR1D | P28221 | 2/20 | 0.78 |
| ▸ | HTR1B | P28222 | 2/20 | 0.78 |
| ▸ | HTR7 | P34969 | 2/20 | 0.78 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.78 |
| ▸ | KCND3 | Q9UK17 | 1/20 | 0.78 |
| ▸ | ACHE | P22303 | 3/20 | 0.69 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19484373 | 0.93 | HTR2A (0.76) | DRD2HTR2ADRD3ADRA2AHTR2C | |
| SCHEMBL12724003 | 0.93 | HTR2A (0.67) | DRD2HTR2ADRD3ADRA2AHTR2C | |
| SCHEMBL18849833 | 0.92 | HTR2A (0.75) | DRD2HTR2ADRD3ADRA2AHTR2C | |
| SCHEMBL6883333 | 0.92 | HTR2A (0.75) | DRD2HTR2ADRD3ADRA2AHTR2C | |
| SCHEMBL3152563 | 0.92 | DRD2 (0.75) | DRD2HTR2ADRD3ADRA2AHTR2C | |
| SCHEMBL3147845 | 0.92 | HTR2A (0.74) | DRD2HTR2ADRD3ADRA2AHTR2C | |
| Hydrochloric Acid SCHEMBL3147935 | 0.92 | HTR2A (0.74) | DRD2HTR2ADRD3ADRA2AHTR2C | |
| SCHEMBL15489518 | 0.92 | DRD2 (0.74) | DRD2HTR2ADRD3ADRA2AHTR2C | |
| SCHEMBL12415616 | 0.92 | DRD2 (0.74) | DRD2HTR2ADRD3ADRA2AHTR2C | |
| SCHEMBL7979151 | 0.91 | DRD2 (0.81) | DRD2HTR2ADRD3ADRA2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2683717-B1 | PREPARATION OF 3-[2-[4-((6-FLUORO-1, 2-BENZISOXAZOL-3-YL)-L-PIPERIDINYL)-6, 7, 8, 9-TETRAHYDRO-9-HYDROXY-2-METHYL-4H-PYRIDO[ 1, 2-A]-PYRIMIDIN-4-ONE (PALIPERIDONE) AND PALIPERIDONE PALMITATE. | RAMAMOHAN RAO DAVULURI (IN) | 2016-05-25 | — | — | EP | disclosed |
| US-8314110-B2 | Compounds for treating mental disorders, and preparation and uses thereof | LI YOUXIN (CN) | 2012-11-20 | — | — | US | disclosed |
| US-20120259116-A1 | Novel Process for the Preparation of Paliperidone | ALKEM LABORATORIES LIMITED (IN) | 2012-10-11 | — | — | US | disclosed |
| US-20120259116-A1 | Novel Process for the Preparation of Paliperidone | ALKEM LABORATORIES LIMITED (IN) | 2012-10-11 | — | — | US | disclosed |
| US-7977480-B2 | Synthesis of paliperidone | SYNTHON BV (NL) | 2011-07-12 | — | — | US | disclosed |
| US-20100113482-A1 | Novel Compounds for Treating Mental Disorders, and Preparation and Uses Thereof | LI YOUXIN | 2010-05-06 | — | — | US | disclosed |
| US-20100010218-A1 | SYNTHESIS OF PALIPERIDONE | SYNTHON BV (NL) | 2010-01-14 | — | — | US | disclosed |
| US-20090209757-A1 | Processes for the preparation and purification of paliperidone palmitate | TEVA PHARMACEUTICALS USA, INC. | 2009-08-20 | — | — | US | disclosed |
| US-20090156810-A1 | SYNTHESIS OF PALIPERIDONE | SYNTHON BV (NL) | 2009-06-18 | — | — | US | disclosed |
| US-20080214808-A1 | Preparation of Aseptic 3-[2-[4-((6-Fluoro-1,2-Benzisoxazol-3-Yl)-1-Piperidinyl]-6,7,8,9-Tetrahydro-9-Hydroxy-2-Methyl-4H-Pyrido[1,2-a]Pyrimidin-4-One Palmitate Ester | SPITTAELS THOMAS FREDERIK ERNESTINE | 2008-09-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100010218-A1 | SYNTHESIS OF PALIPERIDONE | AVPR2, NPPA, GCG | DRD2 1126/4885HTR2A 890/4885DRD3 1723/4885 |
| US-20100113482-A1 | Novel Compounds for Treating Mental Disorders, and Preparation and Uses Thereof | SLC18A2, SLC6A3, SLC6A2 | DRD2 9/4885HTR2A 114/4885DRD3 41/4885 |
| US-20090209757-A1 | Processes for the preparation and purification of paliperidone palmitate | GLP1R, DPP4, ADCYAP1R1 | DRD2 651/4885HTR2A 374/4885DRD3 678/4885 |
| US-20090156810-A1 | SYNTHESIS OF PALIPERIDONE | ACOX1, ALOX15B, ALOX15 | DRD2 1765/4885HTR2A 633/4885DRD3 1065/4885 |
| US-20080214808-A1 | Preparation of Aseptic 3-[2-[4-((6-Fluoro-1,2-Benzisoxazol-3-Yl)-1-Piperidinyl]-6,7,8,9-Tetrahydro-9-Hydroxy-2-Methyl-4H-Pyrido[1,2-a]Pyrimidin-4-One Palmitate Ester | CASP1, FFAR1, FFAR4 | DRD2 3643/4885HTR2A 1860/4885DRD3 3594/4885 |
| US-20120259116-A1 | Novel Process for the Preparation of Paliperidone | PARP16, ADCYAP1R1, AVPR2 | DRD2 1442/4885HTR2A 267/4885DRD3 1758/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.