Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCNN1A | P37088 | 20/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL937634 | 0.99 | SCNN1A (0.60) | SCNN1A | |
| SCHEMBL12251678 | 0.93 | SCNN1A (0.58) | SCNN1A | |
| 552-02 Free Base SCHEMBL2015162 | 0.91 | SCNN1A (0.71) | SCNN1A | |
| 552-02 Free Base SCHEMBL9913774 | 0.91 | SCNN1A (0.71) | SCNN1A | |
| 552-02 Free Base SCHEMBL9913757 | 0.91 | SCNN1A (0.71) | SCNN1A | |
| SCHEMBL12120483 | 0.91 | SCNN1A (0.61) | SCNN1A | |
| 552-02 Free Base SCHEMBL19348088 | 0.90 | SCNN1A (0.70) | SCNN1A | |
| SCHEMBL14268270 | 0.90 | SCNN1A (0.60) | SCNN1A | |
| SCHEMBL14268271 | 0.90 | SCNN1A (0.60) | SCNN1A | |
| SCHEMBL10028716 | 0.90 | SCNN1A (0.60) | SCNN1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8288391-B2 | Epithelial Sodium Channel and Acid Sensitive Ion Channel modulators; blocking or enhancing salt and sour tastes; additives in chocolate, ice cream, beverages, candies, or pet foods; side effect reduction | PARION SCIENCES, INC. (US) | 2012-10-16 | — | — | US | disclosed |
| US-8288391-B2 | Epithelial Sodium Channel and Acid Sensitive Ion Channel modulators; blocking or enhancing salt and sour tastes; additives in chocolate, ice cream, beverages, candies, or pet foods; side effect reduction | PARION SCIENCES, INC. (US) | 2012-10-16 | — | — | US | disclosed |
| US-7981898-B2 | Methods of enhancing mucosal hydration and mucosal clearance by treatment with sodium channel blockers and osmolytes | PARION SCIENCES, INC. (US) | 2011-07-19 | — | — | US | disclosed |
| US-7981898-B2 | Methods of enhancing mucosal hydration and mucosal clearance by treatment with sodium channel blockers and osmolytes | PARION SCIENCES, INC. (US) | 2011-07-19 | — | — | US | disclosed |
| US-7875619-B2 | N-[4-(4-{2-[bis-((2S,3R)-2,3,4-trihydroxybutyl)amino]ethylamino}phenyl)butyl]-N'-(3,5-diamino-6-chloropyrazine-2-carbonyl)guanidine trihydrochloride; treating chronic bronchitis, cystic fibrosis, ventilator-induced pneumonia, asthma, chronic obstructive pulmonary disease, pneumonia and emphysema | PARION SCIENCES, INC. (US) | 2011-01-25 | — | — | US | disclosed |
| US-7875619-B2 | N-[4-(4-{2-[bis-((2S,3R)-2,3,4-trihydroxybutyl)amino]ethylamino}phenyl)butyl]-N'-(3,5-diamino-6-chloropyrazine-2-carbonyl)guanidine trihydrochloride; treating chronic bronchitis, cystic fibrosis, ventilator-induced pneumonia, asthma, chronic obstructive pulmonary disease, pneumonia and emphysema | PARION SCIENCES, INC. (US) | 2011-01-25 | — | — | US | disclosed |
| US-7820678-B2 | Sodium channel blockers | PARION SCIENCES, INC. (US) | 2010-10-26 | — | — | US | disclosed |
| US-7820678-B2 | Sodium channel blockers | PARION SCIENCES, INC. (US) | 2010-10-26 | — | — | US | disclosed |
| US-20100074881-A1 | MULTIPLE NEBULIZER SYSTEMS | PARION SCIENCES, INC. (US) | 2010-03-25 | — | — | US | disclosed |
| US-20100074881-A1 | MULTIPLE NEBULIZER SYSTEMS | PARION SCIENCES, INC. (US) | 2010-03-25 | — | — | US | disclosed |
| US-20080293740-A1 | METHOD OF TREATING ACID-SENSING ION CHANNEL MEDIATED PAIN, COUGH SUPPRESSION, AND CENTRAL NERVOUS SYSTEM DISORDERS | PARION SCIENCES, INC. (US) | 2008-11-27 | — | — | US | disclosed |
| US-20080293740-A1 | METHOD OF TREATING ACID-SENSING ION CHANNEL MEDIATED PAIN, COUGH SUPPRESSION, AND CENTRAL NERVOUS SYSTEM DISORDERS | PARION SCIENCES, INC. (US) | 2008-11-27 | — | — | US | disclosed |
| WO-2008124491-A1 | PYRAZINOYLGUANIDINE COMPOUNDS FOR USE TASTE MODULATORS | PARION SCIENCES, INC. (US) | 2008-10-16 | — | — | WO | disclosed |
| US-20080249109-A1 | PYRAZINOYLGUANIDINE COMPOUNDS FOR USE AS TASTE MODULATORS | PARION SCIENCES, INC. (US) | 2008-10-09 | — | — | US | disclosed |
| US-20080249109-A1 | PYRAZINOYLGUANIDINE COMPOUNDS FOR USE AS TASTE MODULATORS | PARION SCIENCES, INC. (US) | 2008-10-09 | — | — | US | disclosed |
| US-20080076782-A1 | SODIUM CHANNEL BLOCKERS | PARION SCIENCES, INC. (US) | 2008-03-27 | — | — | US | disclosed |
| US-20080076782-A1 | SODIUM CHANNEL BLOCKERS | PARION SCIENCES, INC. (US) | 2008-03-27 | — | — | US | disclosed |
| US-7345044-B2 | Sodium channel blockers | PARION SCIENCES, INC. (US) | 2008-03-18 | — | — | US | disclosed |
| US-7345044-B2 | Sodium channel blockers | PARION SCIENCES, INC. (US) | 2008-03-18 | — | — | US | disclosed |
| WO-2008031048-A2 | ENHANCED MUCOSAL HYDRATION AND MUCOSAL CLEARANCE BY TREATMENT WITH SODIUM CHANNEL BLOCKERS AND OSMOLYTES | PARION SCIENCES, INC. (US) | 2008-03-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080249109-A1 | PYRAZINOYLGUANIDINE COMPOUNDS FOR USE AS TASTE MODULATORS | TAS2R5, TAS2R9, TAS2R19 | SCNN1A 65/4885 |
| US-20080293740-A1 | METHOD OF TREATING ACID-SENSING ION CHANNEL MEDIATED PAIN, COUGH SUPPRESSION, AND CENTRAL NERVOUS SYSTEM DISORDERS | ASIC1, ASIC3, TRPV1 | SCNN1A 75/4885 |
| US-20080076782-A1 | SODIUM CHANNEL BLOCKERS | HCN4, SCN2B, SCN5A | SCNN1A 12/4885 |
| US-20100074881-A1 | MULTIPLE NEBULIZER SYSTEMS | DNM2, MTNR1A, NBAS | SCNN1A 553/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.