Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.51 |
| ▸ | DRD2 | P14416 | 2/20 | 0.51 |
| ▸ | HTR2A | P28223 | 2/20 | 0.51 |
| ▸ | MLNR | O43193 | 1/20 | 0.51 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.51 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.51 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.51 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.51 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.51 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.51 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.51 |
| ▸ | CNR1 | P21554 | 1/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.51 |
| ▸ | NPY1R | P25929 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.51 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6846721 | 1.00 | HTR1A (0.51) | HTR1ADRD2HTR2AMLNRADRB2 | |
| SCHEMBL1734551 | 1.00 | HTR1A (0.51) | HTR1ADRD2HTR2AMLNRADRB2 | |
| SCHEMBL1734549 | 1.00 | HTR1A (0.51) | HTR1ADRD2HTR2AMLNRADRB2 | |
| SCHEMBL10510209 | 0.81 | CYP4F2 (0.36) | HTR1ADRD2HTR2AMLNRADRB2 | |
| SCHEMBL8864150 | 0.81 | ESR1 (0.36) | HTR1ADRD2HTR2AMLNRADRB2 | |
| SCHEMBL27849144 | 0.81 | ESR1 (0.56) | DRD2DRD3OPRK1ESR1ESR2 | |
| SCHEMBL22613778 | 0.81 | ESR1 (0.39) | HTR1ADRD2HTR2AMLNRADRB2 | |
| SCHEMBL27675947 | 0.79 | DRD2 (0.44) | HTR1ADRD2HTR2AMLNRADRB2 | |
| SCHEMBL10510220 | 0.78 | DRD2 (0.37) | HTR1ADRD2HTR2AMLNRADRB2 | |
| SCHEMBL10506849 | 0.77 | DRD2 (0.43) | DRD2DRD3HRH3SRD5A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101020685-A | Synthesis process of 6-fluoro-3,4-dihydro-2H-1-benzopyran-2-epoxy ethane | UNIV ZHEJIANG (CN) | 2007-08-22 | — | — | CN | claimed |
| US-20220056003-A1 | NEBIVOLOL SYNTHESIS METHOD AND INTERMEDIATE COMPOUND THEREOF | ZHEJIANG AUSUN PHARMACEUTICAL CO., LTD. (CN) | 2022-02-24 | — | — | US | disclosed |
| US-11142512-B2 | Nebivolol synthesis method and intermediate compound thereof | ZHEJIANG AUSUN PHARMACEUTICAL CO., LTD. (CN) | 2021-10-12 | — | — | US | disclosed |
| EP-3405467-B1 | PROCESS FOR THE SYNTHESIS OF INTERMEDIATES OF NEBIVOLOL | MENARINI INT OPERATIONS LUXEMBOURG SA (LU) | 2021-08-04 | — | — | EP | disclosed |
| US-20200102282-A1 | NEBIVOLOL SYNTHESIS METHOD AND INTERMEDIATE COMPOUND THEREOF | ZHEJIANG AUSUN PHARMACEUTICAL CO., LTD. (CN) | 2020-04-02 | — | — | US | disclosed |
| US-10392361-B2 | Process for the synthesis of intermediates of Nebivolol | MENARINI INTERNATIONAL OPERATIONS LUXEMBOURG S.A. (LU) | 2019-08-27 | — | — | US | disclosed |
| US-20190031636-A1 | PROCESS FOR THE SYNTHESIS OF INTERMEDIATES OF NEBIVOLOL | MENARINI INTERNATIONAL OPERATIONS LUXEMBOURG S.A. (LU) | 2019-01-31 | — | — | US | disclosed |
| US-20180141926-A1 | NEBIVOLOL SYNTHESIS METHOD AND INTERMEDIATE COMPOUND THEREOF | ZHEJIANG AUSUN PHARMACEUTICAL CO., LTD. (CN) | 2018-05-24 | — | — | US | disclosed |
| US-20180141926-A1 | NEBIVOLOL SYNTHESIS METHOD AND INTERMEDIATE COMPOUND THEREOF | ZHEJIANG AUSUN PHARMACEUTICAL CO., LTD. (CN) | 2018-05-24 | — | — | US | disclosed |
| WO-2017125900-A1 | PROCESS FOR THE SYNTHESIS OF INTERMEDIATES OF NEBIVOLOL | MENARINI INTERNATIONAL OPERATIONS LUXEMBOURG S.A. (LU) | 2017-07-27 | — | — | WO | disclosed |
| US-20130005001-A1 | METHOD FOR PRODUCING NEBIVOLOL | CORDEN PHARMA INTERNATIONAL GMBH | 2013-01-03 | — | — | US | disclosed |
| US-20130005001-A1 | METHOD FOR PRODUCING NEBIVOLOL | CORDEN PHARMA INTERNATIONAL GMBH | 2013-01-03 | — | — | US | disclosed |
| WO-2011091968-A1 | METHOD FOR PRODUCING NEBIVOLOL | CORDEN PHARMACHEM GMBH (DE) | 2011-08-04 | — | — | WO | disclosed |
| US-7560575-B2 | Process for preparation of racemic Nebivolol | ACINO PHARMA AG (CH) | 2009-07-14 | — | — | US | disclosed |
| US-7560575-B2 | Process for preparation of racemic Nebivolol | ACINO PHARMA AG (CH) | 2009-07-14 | — | — | US | disclosed |
| US-20090048457-A1 | PROCESS FOR PREPARATION OF RACEMIC NEBIVOLOL | CIMEX PHARMA AG (CH) | 2009-02-19 | — | — | US | disclosed |
| US-20090048457-A1 | PROCESS FOR PREPARATION OF RACEMIC NEBIVOLOL | CIMEX PHARMA AG (CH) | 2009-02-19 | — | — | US | disclosed |
| CN-101020685-A | Synthesis process of 6-fluoro-3,4-dihydro-2H-1-benzopyran-2-epoxy ethane | UNIV ZHEJIANG (CN) | 2007-08-22 | — | — | CN | disclosed |
| US-20070149612-A1 | Process for preparation of racemic Nebivolol | ACINO PHARMA AG (CH) | 2007-06-28 | — | — | US | disclosed |
| US-20070149612-A1 | Process for preparation of racemic Nebivolol | ACINO PHARMA AG (CH) | 2007-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10392361-B2 | Process for the synthesis of intermediates of Nebivolol | ADRB3, ADRB2, ADRB1 | HTR1A 694/4885DRD2 388/4885HTR2A 658/4885 |
| US-20130005001-A1 | METHOD FOR PRODUCING NEBIVOLOL | ADRA2B, ADRA1B, ADRB2 | HTR1A 1114/4885DRD2 33/4885HTR2A 965/4885 |
| US-20090048457-A1 | PROCESS FOR PREPARATION OF RACEMIC NEBIVOLOL | ADRB1, ADRB2, ADRA2B | HTR1A 101/4885DRD2 60/4885HTR2A 131/4885 |
| US-20200102282-A1 | NEBIVOLOL SYNTHESIS METHOD AND INTERMEDIATE COMPOUND THEREOF | CYP4A11, CYP11B2, ADRB1 | HTR1A 1318/4885DRD2 205/4885HTR2A 1349/4885 |
| US-11142512-B2 | Nebivolol synthesis method and intermediate compound thereof | CYP4A11, CYP11B2, ADRB1 | HTR1A 1318/4885DRD2 205/4885HTR2A 1349/4885 |
| US-20220056003-A1 | NEBIVOLOL SYNTHESIS METHOD AND INTERMEDIATE COMPOUND THEREOF | CYP4A11, CYP11B2, CYP11B1 | HTR1A 1267/4885DRD2 222/4885HTR2A 1351/4885 |
| US-20190031636-A1 | PROCESS FOR THE SYNTHESIS OF INTERMEDIATES OF NEBIVOLOL | ADRB3, ADRB2, ADRB1 | HTR1A 694/4885DRD2 388/4885HTR2A 658/4885 |
| US-20070149612-A1 | Process for preparation of racemic Nebivolol | ADRB1, ADRB2, ADRA2B | HTR1A 101/4885DRD2 60/4885HTR2A 131/4885 |
| US-20180141926-A1 | NEBIVOLOL SYNTHESIS METHOD AND INTERMEDIATE COMPOUND THEREOF | CYP4A11, CYP11B2, ADRB1 | HTR1A 1318/4885DRD2 205/4885HTR2A 1349/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.