Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | TTR | P02766 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | GALR3 | O60755 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | AR | P10275 | 4/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8117922 | 0.87 | ALDH1A1 (0.50) | ALDH1A1MAPTTTRMEN1GALR3 | |
| SCHEMBL4090047 | 0.83 | AR (0.49) | ALDH1A1MAPTMEN1HTTKMT2A | |
| SCHEMBL29061908 | 0.79 | MEN1 (0.53) | ALDH1A1MAPTMEN1GALR3HTT | |
| SCHEMBL515466 | 0.78 | MAPT (0.54) | ALDH1A1MAPTTTRSMN1; SMN2CYP3A4 | |
| SCHEMBL13553414 | 0.78 | NPSR1 (0.42) | ALDH1A1MAPTMEN1GALR3HTT | |
| SCHEMBL31747006 | 0.77 | TSHR (0.54) | ALDH1A1MAPTTTRMEN1KMT2A | |
| SCHEMBL713941 | 0.77 | TSHR (0.54) | ALDH1A1MAPTTTRMEN1KMT2A | |
| SCHEMBL29172509 | 0.76 | MAPT (0.44) | ALDH1A1MAPTTTRMEN1HTT | |
| SCHEMBL21538816 | 0.75 | ALDH1A1 (0.46) | ALDH1A1MAPTTTRMEN1KMT2A | |
| SCHEMBL2345266 | 0.75 | GPR35 (0.58) | ALDH1A1MAPTTTRSMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8895497-B2 | Cathepsin S inhibitors | DCB-USA, LLC (US) | 2014-11-25 | — | — | US | disclosed |
| US-20110166141-A1 | CATHEPSIN S INHIBITORS | DCB-USA, LLC (US) | 2011-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110166141-A1 | CATHEPSIN S INHIBITORS | CTSS, CTSV, CTSB | ALDH1A1 2734/4885MAPT 3934/4885TTR 3722/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.