Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | GPR88 | Q9GZN0 | 2/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | TYR | P14679 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MITF | O75030 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14381016 | 0.85 | LMNA (0.50) | GAAHTTLMNABCHETYR | |
| SCHEMBL6873511 | 0.73 | GPR88 (0.57) | GAAHTTLMNAGPR88KDM4E | |
| SCHEMBL7025851 | 0.73 | ALDH1A1 (0.55) | KMT2AALDH1A1MEN1KDM4ERAB9A | |
| SCHEMBL13464271 | 0.72 | CYP2C9 (0.47) | KMT2AALDH1A1POLBMEN1KDM4E | |
| SCHEMBL16234064 | 0.70 | LMNA (0.48) | GAAHTTLMNABCHETYR | |
| SCHEMBL13035855 | 0.69 | LMNA (0.72) | HTTLMNAKMT2AALDH1A1POLB | |
| SCHEMBL5023224 | 0.68 | NPC1 (0.42) | HTTLMNAKMT2AALDH1A1MEN1 | |
| SCHEMBL13034922 | 0.67 | LMNA (0.56) | GAAHTTLMNAKMT2AALDH1A1 | |
| SCHEMBL30450626 | 0.67 | HTT (0.46) | GAAHTTLMNAKMT2AALDH1A1 | |
| SCHEMBL7040253 | 0.66 | HTT (0.47) | GAAHTTACHEKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2089425-B1 | ANTI-ANGIOGENIC COMPOUNDS | COVX TECHNOLOGIES IRELAND LTD (IE) | 2011-08-17 | — | — | EP | disclosed |