Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
| ▸ | GPR84 | Q9NQS5 | 8/20 | 0.34 |
| ▸ | PPARG | P37231 | 7/20 | 0.34 |
| ▸ | PPARD | Q03181 | 7/20 | 0.34 |
| ▸ | PPARA | Q07869 | 7/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.34 |
| ▸ | TSHR | P16473 | 4/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | TLR2 | O60603 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | FABP4 | P15090 | 2/20 | 0.34 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.34 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2846893 | 0.91 | FDPS (0.36) | AKR1B1GPR84PPARGPPARDPPARA | |
| SCHEMBL12196377 | 0.91 | FDPS (0.36) | AKR1B1GPR84PPARGPPARDPPARA | |
| SCHEMBL1244829 | 0.91 | FDPS (0.36) | AKR1B1GPR84PPARGPPARDPPARA | |
| SCHEMBL707157 | 0.85 | AKR1B1 (0.42) | AKR1B1GPR84PPARGPPARDPPARA | |
| Hydrogen Sulfide SCHEMBL28242647 | 0.83 | AKR1B1 (0.40) | AKR1B1GPR84PPARGPPARDPPARA | |
| SCHEMBL9177480 | 0.83 | CES2 (0.40) | AKR1B1GPR84PPARGPPARDPPARA | |
| SCHEMBL9177227 | 0.83 | AKR1B1 (0.40) | AKR1B1GPR84PPARGPPARDPPARA | |
| SCHEMBL5859801 | 0.83 | AKR1B1 (0.40) | AKR1B1GPR84PPARGPPARDPPARA | |
| SCHEMBL9181451 | 0.83 | AKR1B1 (0.40) | AKR1B1GPR84PPARGPPARDPPARA | |
| SCHEMBL1115982 | 0.81 | AKR1B1 (0.44) | AKR1B1GPR84PPARGPPARDPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114380681-B | Synthesis method of 2- (bromomethyl) -2-butylhexanoic acid | 安徽皓元药业有限公司 | 2024-01-26 | — | — | CN | claimed |
| CN-114380681-A | Synthetic method of 2- (bromomethyl) -2-butyl hexanoic acid | 安徽皓元药业有限公司 | 2022-04-22 | — | — | CN | claimed |
| CN-118834175-A | Benzothiazacycloalkanes Heptatriene compounds use thereof as bile acid modulators | 阿尔比里奥公司 | 2024-10-25 | — | — | CN | disclosed |
| CN-114786773-B | Benzothiazaheterocycles Heptatriene compounds and their use as bile acid modulators | 阿尔比里奥公司 | 2024-10-18 | — | — | CN | disclosed |
| CN-113453753-B | Benzothiazepine compounds and their use as bile acid modulators | 阿尔比里奥公司 | 2024-07-23 | — | — | CN | disclosed |
| US-12024495-B2 | Benzothiazepine compounds and their use as bile acid modulators | ALBIREO AB (SE) | 2024-07-02 | — | — | US | disclosed |
| CN-112449637-B | Benzothiazepine compounds and their use as bile acid modulators | 阿尔比里奥公司 | 2024-03-19 | — | — | CN | disclosed |
| CN-114380681-B | Synthesis method of 2- (bromomethyl) -2-butylhexanoic acid | 安徽皓元药业有限公司 | 2024-01-26 | — | — | CN | disclosed |
| CN-114380681-B | Synthesis method of 2- (bromomethyl) -2-butylhexanoic acid | 安徽皓元药业有限公司 | 2024-01-26 | — | — | CN | disclosed |
| CN-114380681-B | Synthesis method of 2- (bromomethyl) -2-butylhexanoic acid | 安徽皓元药业有限公司 | 2024-01-26 | — | — | CN | disclosed |
| US-11773071-B2 | Benzothiazepine compounds and their use as bile acid modulators | ALBIREO AB (SE) | 2023-10-03 | — | — | US | disclosed |
| CN-106573902-B | Aminoalkyl benzothiazepine derivatives and uses thereof | CJ医药健康株式会社 | 2019-10-08 | — | — | CN | disclosed |
| EP-3210977-B1 | NOVEL AMINOALKYL BENZOTHIAZEPINE DERIVATIVE AND USE THEREOF | CJ HEALTHCARE CORP (KR) | 2019-03-20 | — | — | EP | disclosed |
| US-9890129-B2 | Aminoalkylbenzothiazepine derivatives and uses thereof | CJ HEALTHCARE CORPORATION (KR) | 2018-02-13 | — | — | US | disclosed |
| US-20170283386-A1 | NOVEL AMINOALKYLBENZOTHIAZEPINE DERIVATIVES AND USES THEREOF | CJ HEALTHCARE CORPORATION (KR) | 2017-10-05 | — | — | US | disclosed |
| EP-3210977-A2 | NOVEL AMINOALKYL BENZOTHIAZEPINE DERIVATIVE AND USE THEREOF | CJ Healthcare Corporation (KR) | 2017-08-30 | — | — | EP | disclosed |
| CN-106573902-A | Novel aminoalkylbenzothiazepine derivatives and uses thereof | CJ医药健康株式会社 | 2017-04-19 | — | — | CN | disclosed |
| US-20040077625-A1 | Novel 1,4-benzothiazepine and 1,5-benzothiazepine compounds as inhibitors of apical sodium codependent bile acid transport abd taurocholate uptake | PHARMACIA CORPORATION | 2004-04-22 | — | — | US | disclosed |
| US-20020183307-A1 | Novel 1,4-benzothiazephine and 1,5-benzothiazepine compounds as inhibitors of apical sodium co-dependent bile acid transport and taurocholate uptake | G.D. SEARLE LLC | 2002-12-05 | — | — | US | disclosed |
| WO-2002008211-A2 | BENZOTHIAZEPINES AND THEIR USE AS ANTIHYPERLIPIDEMICS | G.D. SEARLE, LLC. (US) | 2002-01-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11773071-B2 | Benzothiazepine compounds and their use as bile acid modulators | SLC10A1, SLC10A2, ABCB11 | AKR1B1 424/4885GPR84 383/4885PPARG 308/4885 |
| US-12024495-B2 | Benzothiazepine compounds and their use as bile acid modulators | SLC10A1, SLC10A2, ABCB11 | AKR1B1 424/4885GPR84 383/4885PPARG 308/4885 |
| US-20040077625-A1 | Novel 1,4-benzothiazepine and 1,5-benzothiazepine compounds as inhibitors of apical sodium codependent bile acid transport abd taurocholate uptake | SLC10A1, ABCB11, SLC10A2 | AKR1B1 360/4885GPR84 833/4885PPARG 1806/4885 |
| US-20020183307-A1 | Novel 1,4-benzothiazephine and 1,5-benzothiazepine compounds as inhibitors of apical sodium co-dependent bile acid transport and taurocholate uptake | SLC10A1, SLC10A2, ABCB11 | AKR1B1 425/4885GPR84 670/4885PPARG 1374/4885 |
| US-20170283386-A1 | NOVEL AMINOALKYLBENZOTHIAZEPINE DERIVATIVES AND USES THEREOF | SLC10A2, TMPRSS15, HTR5A | AKR1B1 2299/4885GPR84 514/4885PPARG 1856/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.