Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 7/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1245116 | 0.94 | PTGS2 (0.39) | GPBAR1MAPTSCN9AL3MBTL1HPGD | |
| SCHEMBL1246504 | 0.87 | GPBAR1 (0.38) | GPBAR1MAPTSCN9AL3MBTL1HPGD | |
| SCHEMBL1247564 | 0.86 | MAPT (0.42) | GPBAR1MAPTSCN9AL3MBTL1HPGD | |
| SCHEMBL2337989 | 0.85 | LPAR1 (0.38) | GPBAR1MAPTL3MBTL1HPGDALDH1A1 | |
| SCHEMBL1245358 | 0.84 | NR1H4 (0.42) | GPBAR1MAPTSCN9AHPGDALDH1A1 | |
| SCHEMBL1246442 | 0.83 | ALDH1A1 (0.39) | GPBAR1MAPTSCN9AHPGDALDH1A1 | |
| SCHEMBL1246242 | 0.83 | PTGS2 (0.39) | GPBAR1SCN9AHPGDALDH1A1LMNA | |
| SCHEMBL1247211 | 0.83 | FFAR4 (0.42) | GPBAR1MAPTHPGDALDH1A1POLB | |
| SCHEMBL1245152 | 0.83 | NR1H4 (0.42) | GPBAR1MAPTSCN9AHPGDALDH1A1 | |
| SCHEMBL1245320 | 0.82 | NR1H4 (0.45) | GPBAR1MAPTSCN9AHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2462128-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-06-13 | — | — | EP | claimed |
| WO-2011017350-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-02-10 | — | — | WO | claimed |