Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.42 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.39 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.39 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | ADH1B | P00325 | 1/20 | 0.37 |
| ▸ | ADH1C | P00326 | 1/20 | 0.37 |
| ▸ | ADH1A | P07327 | 1/20 | 0.37 |
| ▸ | ADH4 | P08319 | 1/20 | 0.37 |
| ▸ | ADH7 | P40394 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18219144 | 0.87 | — | — | |
| SCHEMBL7945281 | 0.85 | EPHX1 (0.54) | EPHX1HPGDKMT2AALOX5SLC1A3 | |
| SCHEMBL1148328 | 0.85 | EPHX1 (0.54) | EPHX1HPGDKMT2AALOX5SLC1A3 | |
| SCHEMBL3116167 | 0.82 | EPHX1 (0.50) | EPHX1HPGDKMT2AALOX5SLC1A3 | |
| SCHEMBL11974545 | 0.80 | EPHX1 (0.56) | EPHX1HPGDKMT2ACYP2D6ALOX5 | |
| SCHEMBL19606259 | 0.80 | P2RX7 (0.33) | EPHX1HPGDKMT2AALOX5SLC1A3 | |
| SCHEMBL502374 | 0.78 | EPHX1 (0.48) | EPHX1HPGDKMT2AALOX5SLC1A3 | |
| SCHEMBL9159626 | 0.77 | HPGD (0.50) | EPHX1HPGDKMT2ACYP2D6ALOX5 | |
| SCHEMBL18425150 | 0.77 | EPHX1 (0.48) | EPHX1HPGDKMT2ACYP2D6ALOX5 | |
| SCHEMBL9298439 | 0.77 | EPHX1 (0.52) | EPHX1HPGDKMT2AALOX5EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180179187-A1 | Nrf2 REGULATORS | ASTEX THERAPEUTICS LIMITED (GB) | 2018-06-28 | — | — | US | disclosed |
| US-20140228409-A1 | CONDENSED HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2014-08-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180179187-A1 | Nrf2 REGULATORS | NFE2L2, KEAP1, NQO1 | EPHX1 821/4885HPGD 275/4885KMT2A 1359/4885 |
| US-20140228409-A1 | CONDENSED HETEROCYCLIC COMPOUND | RORC, RORB, RORA | EPHX1 2492/4885HPGD 1569/4885KMT2A 180/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.