Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | MMP3 | P08254 | 7/20 | 0.32 |
| ▸ | MMP1 | P03956 | 5/20 | 0.32 |
| ▸ | MMP9 | P14780 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 5/20 | 0.30 |
| ▸ | MMP7 | P09237 | 1/20 | 0.30 |
| ▸ | Q9HBH1 | 1/20 | 0.30 | |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12462670 | 0.81 | ADAM17 (0.36) | ALDH1A1MAPTMMP3MMP1MMP9 | |
| SCHEMBL14865101 | 0.78 | CA1 (0.33) | MMP3MMP1MMP9CYP2D6 | |
| SCHEMBL12175008 | 0.78 | CA1 (0.33) | MMP3MMP1MMP9CYP2D6 | |
| SCHEMBL18675249 | 0.77 | CNR2 (0.38) | CNR2POLBMAPK1ASAH1ALDH1A1 | |
| SCHEMBL12481781 | 0.76 | MMP1 (0.33) | MAPTMMP3MMP1MMP9CYP1A2 | |
| SCHEMBL12482473 | 0.76 | TRPA1 (0.36) | POLBALDH1A1MAPTMMP3MMP1 | |
| SCHEMBL12482098 | 0.76 | ALDH1A1 (0.42) | MAPK1ALDH1A1MMP3MMP1MMP9 | |
| SCHEMBL12468401 | 0.76 | MMP1 (0.33) | MAPTMMP3MMP1MMP9CYP1A2 | |
| SCHEMBL14952312 | 0.76 | MMP3 (0.34) | MMP3MMP1MMP9MMP2MMP7 | |
| SCHEMBL12401321 | 0.76 | L3MBTL1 (0.38) | CNR2POLBMAPK1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110182856-A1 | INHIBITORS OF SERINE PROTEASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-07-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110182856-A1 | INHIBITORS OF SERINE PROTEASES | PRSS1, SPINT2, PRSS2 | CNR2 4814/4885POLB 4161/4885MAPK1 1199/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.