Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALPL | P05186 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | S100A4 | P26447 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | TERT | O14746 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1724293 | 0.81 | ELANE (0.35) | TDP1HPGDMAPTCYP1A2ALDH1A1 | |
| SCHEMBL6981693 | 0.76 | LMNA (0.39) | TDP1HPGDMAPTCYP1A2ALDH1A1 | |
| SCHEMBL24245 | 0.74 | APP (0.35) | CYP3A4S100A4SMN1; SMN2NPC1RAB9A | |
| SCHEMBL18905 | 0.74 | POLB (0.55) | MAPTCYP1A2CYP3A4GAAS100A4 | |
| SCHEMBL5966127 | 0.74 | KDM4E (0.35) | TDP1HPGDMAPTALDH1A1KDM4E | |
| SCHEMBL17438712 | 0.72 | RAB9A (0.47) | HPGDMAPTCYP1A2ALDH1A1KDM4E | |
| SCHEMBL6469994 | 0.72 | RAB9A (0.49) | MAPTALDH1A1KDM4EGAACYP2C9 | |
| SCHEMBL6863661 | 0.72 | ALDH1A1 (0.35) | TDP1HPGDMAPTCYP1A2ALDH1A1 | |
| SCHEMBL1707607 | 0.71 | RAB9A (0.41) | TDP1HPGDMAPTCYP1A2ALDH1A1 | |
| SCHEMBL18230395 | 0.71 | POLB (0.56) | CYP1A2ALDH1A1CYP3A4SMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2283000-B1 | 3- OR 4-SUBSTITUTED PIPERIDINE COMPOUNDS | SK BIOPHARMACEUTICALS CO LTD (KR) | 2015-09-23 | — | — | EP | disclosed |
| US-8546576-B2 | 3 or 4-substituted piperidine compounds | SK BIOPHARMACEUTICALS CO., LTD. (KR) | 2013-10-01 | — | — | US | disclosed |
| US-8513285-B2 | 3 or 4-substituted piperidine compounds | SK BIOPHARMACEUTICALS CO., LTD. (KR) | 2013-08-20 | — | — | US | disclosed |
| US-20120122927-A1 | 3 OR 4-SUBSTITUTED PIPERIDINE COMPOUNDS | LEE KI-HO (KR) | 2012-05-17 | — | — | US | disclosed |
| EP-2283000-A2 | 3- OR 4-SUBSTITUTED PIPERIDINE COMPOUNDS | SK Holdings Co., Ltd. (KR) | 2011-02-16 | — | — | EP | disclosed |
| US-20090306140-A1 | 3 or 4-Substituted Piperidine Compounds | SK BIOPHARMACEUTICALS CO., LTD. (KR) | 2009-12-10 | — | — | US | disclosed |
| WO-2009148291-A2 | 3- OR 4-SUBSTITUTED PIPERIDINE COMPOUNDS | SK HOLDINGS CO., LTD. (KR) | 2009-12-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122927-A1 | 3 OR 4-SUBSTITUTED PIPERIDINE COMPOUNDS | OPRD1, OPRK1, OPRM1 | TDP1 1928/4885HPGD 403/4885SIRT2 2639/4885 |
| US-20090306140-A1 | 3 or 4-Substituted Piperidine Compounds | OPRD1, OPRK1, OPRM1 | TDP1 1922/4885HPGD 426/4885SIRT2 2581/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.