Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.60 |
| ▸ | NPC1 | O15118 | 6/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.55 |
| ▸ | TP53 | P04637 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.54 |
| ▸ | TOP1 | P11387 | 2/20 | 0.53 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.51 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.51 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.50 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.50 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1250383 | 0.88 | RAB9A (0.63) | RAB9ANPC1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL28307210 | 0.88 | TOP1 (0.62) | RAB9ANPC1KMT2AMEN1TP53 | |
| SCHEMBL12706788 | 0.86 | TOP1 (0.72) | RAB9ANPC1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL823156 | 0.84 | RAB9A (0.75) | RAB9ANPC1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL19070454 | 0.83 | MAPT (0.59) | RAB9ANPC1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL20628706 | 0.82 | RAB9A (0.59) | RAB9ANPC1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL11192829 | 0.82 | NPC1 (0.64) | RAB9ANPC1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL6809682 | 0.82 | NPC1 (0.56) | RAB9ANPC1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL13593263 | 0.81 | TOP1 (0.74) | RAB9ANPC1KMT2AMEN1MAPT | |
| SCHEMBL10760743 | 0.81 | RAB9A (0.71) | RAB9ANPC1KMT2AMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074089-B1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2013-09-18 | — | — | EP | disclosed |
| US-8222248-B2 | Organic compounds | NOVARTIS AG (CH) | 2012-07-17 | — | — | US | disclosed |
| US-20110046133-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2011-02-24 | — | — | US | disclosed |
| EP-2074089-A2 | ORGANIC COMPOUNDS | Novartis AG (CH) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008048991-A2 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2008-04-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110046133-A1 | ORGANIC COMPOUNDS | DGAT1, DGAT2, SOAT1 | RAB9A 1888/4885NPC1 32/4885KMT2A 1849/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.