Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.54 |
| ▸ | HPGD | P15428 | 4/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11458159 | 0.82 | ALDH1A1 (0.56) | KDM4EALDH1A1HPGDHSD17B10TP53 | |
| SCHEMBL11470412 | 0.82 | KDM4E (0.46) | KDM4EALDH1A1HPGDTNKS2TP53 | |
| SCHEMBL1771171 | 0.82 | CYP1A2 (0.61) | KDM4EALDH1A1HPGDHSD17B10CYP1A2 | |
| SCHEMBL11826444 | 0.80 | HPGD (0.53) | KDM4EALDH1A1HPGDHSD17B10CYP1A2 | |
| SCHEMBL9549942 | 0.79 | CYP1A2 (0.58) | KDM4EALDH1A1HPGDHSD17B10CYP1A2 | |
| SCHEMBL11466828 | 0.76 | ALDH1A1 (0.53) | KDM4EALDH1A1KMT2AMEN1HTT | |
| SCHEMBL11197750 | 0.76 | KIF11 (0.50) | TP53KMT2AMEN1HTT | |
| SCHEMBL29885154 | 0.76 | GPR84 (0.59) | KDM4EALDH1A1KMT2ATSHRMEN1 | |
| SCHEMBL368690 | 0.76 | GPR84 (0.59) | KDM4EALDH1A1KMT2ATSHRMEN1 | |
| SCHEMBL27317234 | 0.75 | CYP1A2 (0.53) | KDM4EALDH1A1HPGDHSD17B10CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7879877-B2 | orally administering 2-(4-chlorobenzoylamino)-3-(2-quinolon-4-yl)propionic acid, for the prophylaxis and/or treatment of xerostomia | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2011-02-01 | — | — | US | disclosed |
| CN-1859948-B | Carbostyril derivatives for accelerating salivation | OTSUKA PHARMA CO LTD | 2010-05-26 | — | — | CN | disclosed |
| US-20070112026-A1 | Carbostyril derivatives for accelerating salivation | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2007-05-17 | — | — | US | disclosed |
| CN-1859948-A | Carbostyril derivatives for accelerating salivation | OTSUKA PHARMA CO LTD (JP) | 2006-11-08 | — | — | CN | disclosed |
| EP-1706383-A1 | AMINE SALT OF CARBOSTYRIL DERIVATIVE | Otsuka Pharmaceutical Company, Limited (JP) | 2006-10-04 | — | — | EP | disclosed |
| WO-2005070892-A1 | AMINE SALT OF CARBOSTYRIL DERIVATIVE | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2005-08-04 | — | — | WO | disclosed |
| CN-1117268-A | Carbostyril derivative for inhibiting production of interleukin-8 | OTSUKA PHARMA CO LTD (JP) | 1996-02-21 | — | — | CN | disclosed |
| US-4187310-A | ANTIINFLAMMATORY AGENT, ANALGESICS, ENZYME INHIBITORS | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1980-02-05 | — | — | US | disclosed |
| US-4138490-A | Analgesic compositions containing 1,2-dihydro-2-oxoquinol-4-ylpropionic acid derivatives | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1979-02-06 | — | — | US | disclosed |
| US-4138490-A | Analgesic compositions containing 1,2-dihydro-2-oxoquinol-4-ylpropionic acid derivatives | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1979-02-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070112026-A1 | Carbostyril derivatives for accelerating salivation | TAS2R40, TAS2R41, TAS2R42 | KDM4E 3504/4885ALDH1A1 3460/4885HPGD 2266/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.