SCHEMBL12569770

SCHEMBL12569770

NC(=O)CCN(C(=O)c1ccccc1)c1cccc(C(=O)Nc2c(Br)cc(C(F)(C(F)(F)F)C(F)(F)F)cc2C(F)(F)F)c1F

nearest known ligand 0.34

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
KCNK3 O14649 2/20 0.34
KCNK9 Q9NPC2 2/20 0.34
MEN1 O00255 1/20 0.33
LMNA P02545 1/20 0.33
MAPT P10636 1/20 0.33
KMT2A Q03164 1/20 0.33
SMN1; SMN2 Q16637 2/20 0.32
F2 P00734 2/20 0.32
PTGES O14684 3/20 0.31
RXFP1 Q9HBX9 3/20 0.31
PTGS1 P23219 1/20 0.31
HDAC8 Q9BY41 1/20 0.30
EPHX1 P07099 1/20 0.30
F2R P25116 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12569765 0.94 F2R (0.32) KCNK3KCNK9MEN1KMT2ASMN1; SMN2
SCHEMBL12569845 0.91 RXFP1 (0.35) RXFP1
SCHEMBL29028658 0.89 PTGES (0.36) KCNK3KCNK9MEN1LMNAMAPT
SCHEMBL28630497 0.89 MLYCD (0.36) KCNK3KCNK9MEN1LMNAMAPT
SCHEMBL31679336 0.89 TSHR (0.38) KCNK3KCNK9MEN1LMNAMAPT
SCHEMBL28621340 0.89 TSHR (0.38) KCNK3KCNK9MEN1LMNAMAPT
SCHEMBL29114034 0.88 PTGES (0.35) KCNK3KCNK9MEN1LMNAMAPT
SCHEMBL29114043 0.87 CTSS (0.35) KCNK3KCNK9MEN1LMNAMAPT
SCHEMBL12570072 0.87 POLB (0.35) KCNK3KCNK9F2RXFP1
SCHEMBL24914497 0.86 POLQ (0.38) KCNK3KCNK9MEN1LMNAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2325165-B1 AMIDE DERIVATIVE, PEST CONTROL AGENT CONTAINING THE AMIDE DERIVATIVE AND PEST CONTROLLING METHOD MITSUI CHEMICALS AGRO INC (JP) 2020-02-19 EP disclosed
EP-3205642-A2 AMIDE DERIVATIVE, PEST CONTROL AGENT CONTAINING THE AMIDE DERIVATIVE AND PEST CONTROLLING METHOD Mitsui Chemicals Agro, Inc. (JP) 2017-08-16 EP disclosed
US-9084420-B2 Amide derivative, pest control agent containing the amide derivative, and pest controlling method MITSUI CHEMICALS AGRO, INC. (JP) 2015-07-21 US disclosed
US-20140107368-A1 AMIDE DERIVATIVE, PEST CONTROL AGENT CONTAINING THE AMIDE DERIVATIVE, AND PEST CONTROLLING METHOD MITSUI CHEMICALS AGRO, INC. (JP) 2014-04-17 US disclosed
US-8633228-B2 Amide derivative, pest control agent containing the amide derivative, and pest controlling method MITSUI CHEMICALS AGRO, INC. (JP) 2014-01-21 US disclosed
CN-102112437-A Amide derivative, pest control agent containing same, and pest control method MITSUI CHEMICALS AGRO INC 2011-06-29 CN disclosed
US-20110136878-A1 AMIDE DERIVATIVE, PEST CONTROL AGENT CONTAINING THE AMIDE DERIVATIVE, AND PEST CONTROLLING METHOD Mitsui Chemicals Agro., Inc. (JP) 2011-06-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110136878-A1 AMIDE DERIVATIVE, PEST CONTROL AGENT CONTAINING THE AMIDE DERIVATIVE, AND PEST CONTROLLING METHOD L3MBTL1, L3MBTL4, L3MBTL3 KCNK3 889/4885KCNK9 1103/4885MEN1 3215/4885
US-20140107368-A1 AMIDE DERIVATIVE, PEST CONTROL AGENT CONTAINING THE AMIDE DERIVATIVE, AND PEST CONTROLLING METHOD L3MBTL1, L3MBTL4, L3MBTL3 KCNK3 889/4885KCNK9 1103/4885MEN1 3215/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.