Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLM | Q9NP87 | 2/20 | 0.59 |
| ▸ | POLK | Q9UBT6 | 2/20 | 0.59 |
| ▸ | POLL | Q9UGP5 | 2/20 | 0.59 |
| ▸ | POLH | Q9Y253 | 2/20 | 0.59 |
| ▸ | HTR2A | P28223 | 4/20 | 0.50 |
| ▸ | ELANE | P08246 | 1/20 | 0.47 |
| ▸ | FAAH | O00519 | 4/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.44 |
| ▸ | DGKA | P23743 | 1/20 | 0.43 |
| ▸ | SOAT2 | O75908 | 1/20 | 0.43 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.42 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30666136 | 0.83 | POLM (0.67) | POLMPOLKPOLLPOLHHTR2A | |
| SCHEMBL7285448 | 0.82 | KMT2A (0.57) | POLMPOLKPOLLPOLHKDM4E | |
| SCHEMBL17138174 | 0.82 | POLM (0.62) | POLMPOLKPOLLPOLHKDM4E | |
| SCHEMBL11044984 | 0.81 | POLM (0.58) | POLMPOLKPOLLPOLHHTR2A | |
| SCHEMBL8176587 | 0.80 | POLM (0.64) | POLMPOLKPOLLPOLHHTR2A | |
| SCHEMBL8176584 | 0.80 | POLM (0.57) | POLMPOLKPOLLPOLHFAAH | |
| SCHEMBL17372978 | 0.79 | POLM (0.57) | POLMPOLKPOLLPOLHHTR2A | |
| SCHEMBL22261900 | 0.79 | POLM (0.62) | POLMPOLKPOLLPOLHHTR2A | |
| SCHEMBL20739827 | 0.79 | POLM (0.62) | POLMPOLKPOLLPOLHHTR2A | |
| SCHEMBL26090058 | 0.79 | POLM (0.62) | POLMPOLKPOLLPOLHHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110092739-A1 | Lipid Nanoparticle Based Compositions and Methods for the Delivery of Biologically Active Molecules | SIMA THERAPEUTICS, INC. (US) | 2011-04-21 | — | — | US | disclosed |
| US-7893302-B2 | novel cationic lipids based on 4-(aminomethyl)-1,2-bis-(fatty ether or ester)-benzene | SIRNA THERAPEUTICS, INC. (US) | 2011-02-22 | — | — | US | disclosed |
| US-20100105933-A1 | LIPID NANOPARTICLE BASED COMPOSITIONS AND METHODS FOR THE DELIVERY OF BIOLOGICALLY ACTIVE MOLECULES | CHEN TONGQIAN | 2010-04-29 | — | — | US | disclosed |
| US-7691405-B2 | Lipid nanoparticle based compositions and methods for the delivery of biologically active molecules | SIRNA THERAPEUTICS, INC (US) | 2010-04-06 | — | — | US | disclosed |
| US-20100063308-A1 | LIPID NANOPARTICLE BASED COMPOSITIONS AND METHODS FOR THE DELIVERY OF BIOLOGICALLY ACTIVE MOLECULES | BANK OF AMERICA, N.A. | 2010-03-11 | — | — | US | disclosed |
| US-20100048888-A1 | Lipid Nanoparticle Based Compositions and Methods for the Delivery of Biologically Active Molecules | SIRNA THERAPEUTICS, INC., A WHOLLY OWNED SUBSIDIARY OF MERCK & CO., INC. | 2010-02-25 | — | — | US | disclosed |
| US-20100015218-A1 | COMPOSITIONS AND METHODS FOR POTENTIATED ACTIVITY OF BIOLOGICALLY ACTIVE MOLECULES | MERCK SHARP & DOHME CORP. | 2010-01-21 | — | — | US | disclosed |
| US-7641915-B2 | Lipid nanoparticle based compositions and methods for the delivery of biologically active molecules | SIRNA THERAPEUTICS, INC (US) | 2010-01-05 | — | — | US | disclosed |
| EP-2131848-A2 | COMPOSITIONS AND METHODS FOR POTENTIATED ACTIVITY OF BIOLOGICALY ACTIVE MOLECULES | Merck & Co., Inc. (US) | 2009-12-16 | — | — | EP | disclosed |
| EP-2104740-A2 | LIPID NANOPARTICLE BASED COMPOSITIONS AND METHODS FOR THE DELIVERY OF BIOLOGICALLY ACTIVE MOLECULES | Sirna Therapeutics, Inc. (US) | 2009-09-30 | — | — | EP | disclosed |
| US-20090048197-A1 | Lipid Nanoparticle Based Compositions and Methods for the Delivery of Biologically Active Molecules | SIRNA THERAPEUTICS, INC. (US) | 2009-02-19 | — | — | US | disclosed |
| WO-2008147438-A2 | LIPID NANOPARTICLE BASED COMPOSITIONS AND METHODS FOR THE DELIVERY OF BIOLOGICALLY ACTIVE MOLECULES | SIRNA THERAPEUTICS, INC. (US) | 2008-12-04 | — | — | WO | disclosed |
| WO-2008103276-A2 | COMPOSITIONS AND METHODS FOR POTENTIATED ACTIVITY OF BIOLOGICALY ACTIVE MOLECULES | MERCK & CO., INC. (US) | 2008-08-28 | — | — | WO | disclosed |
| US-20080188675-A1 | LIPID NANOPARTICLE BASED COMPOSITIONS AND METHODS FOR THE DELIVERY OF BIOLOGICALLY ACTIVE MOLECULES | SIRNA THERAPEUTICS INC. (US) | 2008-08-07 | — | — | US | disclosed |
| US-7404969-B2 | Lipid nanoparticle based compositions and methods for the delivery of biologically active molecules | SIRNA THERAPEUTICS, INC. (US) | 2008-07-29 | — | — | US | disclosed |
| EP-1922300-A2 | CATIONIC LIPIDS AND FORMULATED MOLECULAR COMPOSITIONS CONTAINING THEM | Sirna Therapeutics Inc. (US) | 2008-05-21 | — | — | EP | disclosed |
| US-20080020058-A1 | Lipid nanoparticle based compositions and methods for the delivery of biologically active molecules | SIRNA THERAPEUTICS, INC. (US) | 2008-01-24 | — | — | US | disclosed |
| WO-2007086883-A2 | CATIONIC LIPIDS AND FORMULATED MOLECULAR COMPOSITIONS CONTAINING THEM | SIRNA THERAPEUTICS, INC. (US) | 2007-08-02 | — | — | WO | disclosed |
| WO-2007086881-A2 | CATIONIC LIPIDS AND FORMULATED MOLECULAR COMPOSITIONS CONTAINING THEM | SIRNA THERAPEUTICS, INC. (US) | 2007-08-02 | — | — | WO | disclosed |
| US-20060240554-A1 | Lipid nanoparticle based compositions and methods for the delivery of biologically active molecules | SIRNA THERAPEUTICS, INC. (US) | 2006-10-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110092739-A1 | Lipid Nanoparticle Based Compositions and Methods for the Delivery of Biologically Active Molecules | PHAX, CETP, LIPC | POLM 274/4885POLK 1912/4885POLL 2836/4885 |
| US-20090048197-A1 | Lipid Nanoparticle Based Compositions and Methods for the Delivery of Biologically Active Molecules | PHAX, CETP, LIPC | POLM 292/4885POLK 1985/4885POLL 2946/4885 |
| US-20100048888-A1 | Lipid Nanoparticle Based Compositions and Methods for the Delivery of Biologically Active Molecules | PHAX, CETP, LIPC | POLM 292/4885POLK 1985/4885POLL 2946/4885 |
| US-20100063308-A1 | LIPID NANOPARTICLE BASED COMPOSITIONS AND METHODS FOR THE DELIVERY OF BIOLOGICALLY ACTIVE MOLECULES | PHAX, CETP, LIPC | POLM 274/4885POLK 1912/4885POLL 2836/4885 |
| US-20060240554-A1 | Lipid nanoparticle based compositions and methods for the delivery of biologically active molecules | PHAX, CETP, LIPC | POLM 274/4885POLK 1912/4885POLL 2836/4885 |
| US-20080020058-A1 | Lipid nanoparticle based compositions and methods for the delivery of biologically active molecules | PHAX, CETP, LIPC | POLM 292/4885POLK 1985/4885POLL 2946/4885 |
| US-20100105933-A1 | LIPID NANOPARTICLE BASED COMPOSITIONS AND METHODS FOR THE DELIVERY OF BIOLOGICALLY ACTIVE MOLECULES | PHAX, CETP, LIPC | POLM 292/4885POLK 1985/4885POLL 2946/4885 |
| US-20100015218-A1 | COMPOSITIONS AND METHODS FOR POTENTIATED ACTIVITY OF BIOLOGICALLY ACTIVE MOLECULES | PHAX, MTREX, CHIA | POLM 254/4885POLK 1628/4885POLL 3229/4885 |
| US-20080188675-A1 | LIPID NANOPARTICLE BASED COMPOSITIONS AND METHODS FOR THE DELIVERY OF BIOLOGICALLY ACTIVE MOLECULES | PHAX, CETP, LIPC | POLM 274/4885POLK 1912/4885POLL 2836/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.