Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | KIF11 | P52732 | 4/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | PGR | P06401 | 1/20 | 0.48 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12054668 | 0.83 | KEAP1 (0.75) | KEAP1ALDH1A1SMN1; SMN2HTTLMNA | |
| SCHEMBL31041151 | 0.77 | KIF11 (0.79) | KEAP1ALDH1A1SMN1; SMN2HTTLMNA | |
| SCHEMBL10138647 | 0.76 | KEAP1 (0.53) | KEAP1ALDH1A1SMN1; SMN2HTTLMNA | |
| Lithium SCHEMBL31041154 | 0.75 | KIF11 (0.76) | KEAP1ALDH1A1SMN1; SMN2HTTLMNA | |
| SCHEMBL1488032 | 0.75 | ALDH1A1 (0.68) | KEAP1ALDH1A1SMN1; SMN2HTTLMNA | |
| SCHEMBL82733 | 0.75 | CA1 (0.64) | KEAP1ALDH1A1SMN1; SMN2HTTLMNA | |
| SCHEMBL522309 | 0.75 | KEAP1 (0.62) | KEAP1ALDH1A1SMN1; SMN2HTTLMNA | |
| SCHEMBL24689849 | 0.74 | LMNA (0.66) | KEAP1ALDH1A1SMN1; SMN2HTTLMNA | |
| SCHEMBL3315266 | 0.73 | KEAP1 (0.60) | KEAP1ALDH1A1SMN1; SMN2HTTLMNA | |
| SCHEMBL479173 | 0.73 | KIF11 (0.88) | KEAP1ALDH1A1SMN1; SMN2HTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110144110-A1 | Novel Pyrrole Inhibitors of S-Nitrosoglutathione Reductase as Therapeutic Agents | N30 PHARMACEUTICALS, LLC (US) | 2011-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110144110-A1 | Novel Pyrrole Inhibitors of S-Nitrosoglutathione Reductase as Therapeutic Agents | GSR, DHFR, GRHPR | KEAP1 439/4885ALDH1A1 449/4885SMN1; SMN2 4514/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.