SCHEMBL1268650

SCHEMBL1268650

O=[C]c1ccccc1C(Br)Br

nearest known ligand 0.32

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.32
CYP1A2 P05177 1/20 0.32
CYP2C9 P11712 1/20 0.32
CYP2C19 P33261 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9744159 0.82 P2RX7 (0.35) ALDH1A1CYP1A2CYP2C9CYP2C19
SCHEMBL5808123 0.76 TSHR (0.35)
SCHEMBL11414735 0.76 TSHR (0.44) ALDH1A1CYP1A2CYP2C9CYP2C19
SCHEMBL535464 0.76 GABRA1 (0.44) ALDH1A1CYP1A2CYP2C19
SCHEMBL5521697 0.76
SCHEMBL20141749 0.76
SCHEMBL9036599 0.73 CYP2D6 (0.41) ALDH1A1CYP1A2
SCHEMBL8507192 0.73 ALDH1A1 (0.39) ALDH1A1
SCHEMBL8384 0.73 TSHR (0.35) ALDH1A1CYP1A2CYP2C9CYP2C19
SCHEMBL655520 0.73 CYP1A2 (0.43) ALDH1A1CYP1A2CYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 290 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040142946-A1 Modified nucleosides and nucleotides and use thereof CHATTOPADHYAYA JYOTI (SE) 2004-07-22 US claimed
EP-1332150-A1 MODIFIED NUCLEOSIDES AND NUCLEOTIDES AND USE THEREOF Chattopadhyaya, Jyoti (SE) 2003-08-06 EP claimed
WO-2002038578-A1 MODIFIED NUCLEOSIDES AND NUCLEOTIDES AND USE THEREOF CHATTOPADHYAYA JYOTI (SE) 2002-05-16 WO claimed
US-5837873-A PROTECTED OXYDIAMINES ABBOTT LABORATORIES (US) 1998-11-17 US claimed
US-5721350-A Deuterated nucleosides CHATTOPADHYAYA JYOTI (SE) 1998-02-24 US claimed
US-5430139-A Viricides; effective against herpes and cytomegalo viruses YAMASA SHOYU KABUSHIKI KAISHA (JP) 1995-07-04 US claimed
EP-0648220-A1 DEUTERATED NUCLEOSIDES CHATTOPADHYAYA, Jyoti (SE) 1995-04-19 EP claimed
US-5300636-A 2'-alkylidenepyrimidine nucleoside compounds and a process for production of same YAMASA SHOYU KABUSHIKI KAISHA (JP) 1994-04-05 US claimed
WO-1993025566-A1 DEUTERATED NUCLEOSIDES CHATTOPADHYAYA JYOTI (SE) 1993-12-23 WO claimed
US-5189027-A Hypotensive agent, vasoconstriction YAMASA SHOYU KABUSHIKI KAISHA (JP) 1993-02-23 US claimed
US-5068340-A Antagonist of platelet activating factor for treatment of asthma, inflammation or shock SANKYO COMPANY, LIMITED (JP) 1991-11-26 US claimed
US-20240238321-A1 MODIFIED OLIGOMERIC COMPOUNDS COMPRISING TRICYCLO-DNA NUCLEOSIDES AND USES THEREOF SYNTHENA AG (CH) 2024-07-18 US disclosed
CN-118355117-A Oligonucleotide compositions and methods thereof 波涛生命科学有限公司 2024-07-16 CN disclosed
US-20240229026-A1 CHIRAL CONTROL WAVE LIFE SCIENCES LTD. (SG) 2024-07-11 US disclosed
WO-2024148274-A1 COMPLEMENT INHIBITION APELLIS PHARMACEUTICALS, INC. (US) 2024-07-11 WO disclosed
US-4783532-A Process for preparing griseolic acid derivatives SANKYO COMPANY LIMITED (JP) 1988-11-08 US disclosed
EP-0260121-A2 Inosose derivatives, production and use thereof Takeda Chemical Industries, Ltd. (JP) 1988-03-16 EP disclosed
EP-0240175-A1 Inosose derivatives and production thereof Takeda Chemical Industries, Ltd. (JP) 1987-10-07 EP disclosed
EP-0238202-A2 Glycerol derivatives, their preparation and their therapeutic use Sankyo Company Limited (JP) 1987-09-23 EP disclosed
EP-0200522-A2 Process for preparing griseolic acid derivatives SANKYO COMPANY LIMITED (JP) 1986-11-05 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040142946-A1 Modified nucleosides and nucleotides and use thereof RNASEH1, RNASEL, NSUN2 ALDH1A1 4684/4885CYP1A2 3206/4885CYP2C9 2499/4885
US-20240229026-A1 CHIRAL CONTROL RNGTT, POLI, NSUN3 ALDH1A1 2867/4885CYP1A2 4590/4885CYP2C9 3989/4885
US-20240238321-A1 MODIFIED OLIGOMERIC COMPOUNDS COMPRISING TRICYCLO-DNA NUCLEOSIDES AND USES THEREOF MTPN, UTRN, DCTD ALDH1A1 3954/4885CYP1A2 4607/4885CYP2C9 4552/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.