Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.67 |
| ▸ | HTT | P42858 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.57 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | PYGL | P06737 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16127861 | 0.82 | CREBBP (0.69) | KMT2AHTTSMN1; SMN2PLA2G1BATG4B | |
| SCHEMBL6802094 | 0.80 | KMT2A (1.00) | KMT2AHTTSMN1; SMN2MEN1RAB9A | |
| SCHEMBL12172753 | 0.79 | KMT2A (0.67) | KMT2ARAB9AALDH1A1TDP1L3MBTL1 | |
| SCHEMBL975946 | 0.79 | KDM4E (0.55) | KMT2AHTTSMN1; SMN2PLA2G1BATG4B | |
| SCHEMBL5896940 | 0.79 | L3MBTL1 (0.74) | KMT2AMEN1RAB9AALDH1A1TDP1 | |
| SCHEMBL4585373 | 0.79 | HTT (0.55) | KMT2AHTTSMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL18132555 | 0.77 | TAS2R14 (0.67) | KMT2AHTTMEN1RAB9ATAS2R14 | |
| SCHEMBL2058331 | 0.77 | ALDH1A1 (0.68) | KMT2ASMN1; SMN2MEN1RAB9AALDH1A1 | |
| SCHEMBL7820773 | 0.77 | KMT2A (0.71) | KMT2AHTTSMN1; SMN2MEN1RAB9A | |
| SCHEMBL12700358 | 0.77 | ALDH1A1 (0.66) | KMT2ASMN1; SMN2MEN1TAS2R14ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10166237-B2 | Compounds and methods for inducing chondrogenesis | THE SCRIPPS RESEARCH INSTITUTE (US) | 2019-01-01 | — | — | US | disclosed |
| US-20170112843-A1 | COMPOUNDS AND METHODS FOR INDUCING CHONDROGENESIS | THE SCRIPPS RESEARCH INSTITUTE | 2017-04-27 | — | — | US | disclosed |
| US-9464065-B2 | Compounds and methods for inducing chondrogenesis | THE SCRIPPS RESEARCH INSTITUTE (US) | 2016-10-11 | — | — | US | disclosed |
| WO-2012129562-A2 | COMPOUNDS AND METHODS FOR INDUCING CHONDROGENESIS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2012-09-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10166237-B2 | Compounds and methods for inducing chondrogenesis | COL2A1, BMP4, BMP2 | KMT2A 3000/4885HTT 3563/4885SMN1; SMN2 3908/4885 |
| US-20170112843-A1 | COMPOUNDS AND METHODS FOR INDUCING CHONDROGENESIS | COL2A1, BMP4, BMP2 | KMT2A 3000/4885HTT 3563/4885SMN1; SMN2 3908/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.