Sugi Predict

Sugi Predict / Compounds / SCHEMBL12704178

SCHEMBL12704178

SCHEMBL12704178

O=C(Cl)Cc1cc(Cl)cc(Cl)c1

nearest known ligand 0.42

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ TPMT P51580 1/20 0.42
▸ TSHR P16473 1/20 0.40
▸ IDO1 P14902 2/20 0.39
▸ ACLY P53396 1/20 0.37
▸ CNR1 P21554 1/20 0.37
▸ CTBP2 P56545 2/20 0.36
▸ TACR1 P25103 1/20 0.36
▸ P2RX7 Q99572 1/20 0.35
▸ HTR3E A5X5Y0 1/20 0.34
▸ HTR3B O95264 1/20 0.34
▸ HTR3A P46098 1/20 0.34
▸ HTR3D Q70Z44 1/20 0.34
▸ HTR3C Q8WXA8 1/20 0.34
▸ RXRA P19793 1/20 0.34
▸ RXRB P28702 1/20 0.34
▸ RAB9A P51151 1/20 0.34
▸ EPHX1 P07099 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5194940 0.84 GPR84 (0.37) TSHR
SCHEMBL27406782 0.80 MARS1 (0.43) CNR1CTBP2
SCHEMBL22774078 0.80 SMN1; SMN2 (0.36) CNR1TACR1RAB9A
SCHEMBL22775743 0.80 SLC13A3 (0.42) CNR1TACR1RXRARXRB
SCHEMBL868125 0.80 CA2 (0.50) TPMTTSHRACLY
SCHEMBL4187668 0.78 IDO1 (0.37) IDO1RAB9AEPHX1
SCHEMBL48901 0.78 IDO1 (0.43) TPMTTSHRIDO1ACLYCNR1
SCHEMBL4201900 0.78 THRB (0.36) IDO1RAB9A
SCHEMBL3340425 0.78 CA2 (0.46) TPMTTSHRIDO1HTR3EHTR3B
SCHEMBL10744564 0.78 TPMT (0.41) TPMTTSHRIDO1ACLYCNR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12559503-B2 Anthelmintic aza-benzothiophene and aza-benzofuran compounds BOEHRINGER INGELHEIM VETMEDICA GMBH (DE) 2026-02-24 — — US disclosed
CN-119775103-B Resveratrol and preparation method and application thereof 湖南复瑞生物医药技术有限责任公司 2025-05-27 — — CN disclosed
CN-119775103-A Resveratrol and preparation method and application thereof 湖南复瑞生物医药技术有限责任公司 2025-04-08 — — CN disclosed
CN-119285648-A Insect repellent aza-benzothiophenes and aza-benzofuran compounds 勃林格殷格翰动物保健有限公司 2025-01-10 — — CN disclosed
CN-113825543-B Insect repellent aza-benzothiophenes and aza-benzofuran compounds 勃林格殷格翰动物保健有限公司 2024-09-06 — — CN disclosed
US-20230219974-A1 ANTHELMINTIC AZA-BENZOTHIOPHENE AND AZA-BENZOFURAN COMPOUNDS BOEHRINGER INGELHEIM VETMEDICA GMBH (DE) 2023-07-13 — — US disclosed
US-20230219974-A1 ANTHELMINTIC AZA-BENZOTHIOPHENE AND AZA-BENZOFURAN COMPOUNDS BOEHRINGER INGELHEIM VETMEDICA GMBH (DE) 2023-07-13 — — US disclosed
US-20230219974-A1 ANTHELMINTIC AZA-BENZOTHIOPHENE AND AZA-BENZOFURAN COMPOUNDS BOEHRINGER INGELHEIM VETMEDICA GMBH (DE) 2023-07-13 — — US disclosed
US-11560388-B2 Anthelmintic aza-benzothiophene and aza-benzofuran compounds BOEHRINGER INGELHEIM VETMEDICA GMBH 2023-01-24 — — US disclosed
US-11560388-B2 Anthelmintic aza-benzothiophene and aza-benzofuran compounds BOEHRINGER INGELHEIM VETMEDICA GMBH 2023-01-24 — — US disclosed
US-7893098-B2 Pyrrole and pyrazole DAAO inhibitors SEPRACOR INC. (US) 2011-02-22 — — US disclosed
US-7893098-B2 Pyrrole and pyrazole DAAO inhibitors SEPRACOR INC. (US) 2011-02-22 — — US disclosed
US-20100016397-A1 Pyrrole and Pyrazole DAAO Inhibitors SEPRACOR INC. (US) 2010-01-21 — — US disclosed
US-20100016397-A1 Pyrrole and Pyrazole DAAO Inhibitors SEPRACOR INC. (US) 2010-01-21 — — US disclosed
US-7615572-B2 4,5-substituted pyrazole-3-carboxylic acids/esters/salts; D-amino acid oxidase (DAAO) inhibitors; increase D-Serine level; reduce level of toxic products of D-Serine oxidation; activate N-methyl-D-aspartate NMDA-glutamate receptors; neuropathic agent, schizophrenia, Alzheimer's, anaxia SEPRACOR INC. (US) 2009-11-10 — — US disclosed
US-7615572-B2 4,5-substituted pyrazole-3-carboxylic acids/esters/salts; D-amino acid oxidase (DAAO) inhibitors; increase D-Serine level; reduce level of toxic products of D-Serine oxidation; activate N-methyl-D-aspartate NMDA-glutamate receptors; neuropathic agent, schizophrenia, Alzheimer's, anaxia SEPRACOR INC. (US) 2009-11-10 — — US disclosed
US-20090170916-A1 Pyrrole and Pyrazole DAAO Inhibitors SEPRACOR INC. (US) 2009-07-02 — — US disclosed
US-20090170916-A1 Pyrrole and Pyrazole DAAO Inhibitors SEPRACOR INC. (US) 2009-07-02 — — US disclosed
US-7488747-B2 Pyrrole and pyrazole DAAO inhibitors SEPRACOR INC. (US) 2009-02-10 — — US disclosed
US-7488747-B2 Pyrrole and pyrazole DAAO inhibitors SEPRACOR INC. (US) 2009-02-10 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100016397-A1 Pyrrole and Pyrazole DAAO Inhibitors DDO, DAO, SRR TPMT 785/4885TSHR 1282/4885IDO1 2500/4885
US-11560388-B2 Anthelmintic aza-benzothiophene and aza-benzofuran compounds TPMT, NAT1, HNMT TPMT 1/4885TSHR 4263/4885IDO1 274/4885
US-20230219974-A1 ANTHELMINTIC AZA-BENZOTHIOPHENE AND AZA-BENZOFURAN COMPOUNDS TPMT, NAT1, HNMT TPMT 1/4885TSHR 4263/4885IDO1 274/4885
US-20090170916-A1 Pyrrole and Pyrazole DAAO Inhibitors DDO, DAO, SRR TPMT 785/4885TSHR 1282/4885IDO1 2500/4885
US-12559503-B2 Anthelmintic aza-benzothiophene and aza-benzofuran compounds HDAC5, NR5A2, HRH4 TPMT 28/4885TSHR 804/4885IDO1 501/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.