SCHEMBL127648

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL5384551	0.82	AKT1 (0.44)	OPRD1CTSSL3MBTL1TDP1MEN1
	SCHEMBL9995389	0.82	CHRNB2 (0.53)	CHRNB2CHRNB4CHRNA3CHRNA4OPRM1
	SCHEMBL16681724	0.82	CHRNB2 (0.53)	CHRNB2CHRNB4CHRNA3CHRNA4OPRM1
	SCHEMBL11990750	0.79	CHRNB2 (0.54)	CHRNB2CHRNB4CHRNA3CHRNA4L3MBTL1
	SCHEMBL5654433	0.79	RIPK1 (0.51)	CTSSCTSKL3MBTL1KDM4EALDH1A1
	SCHEMBL28857505	0.79	RIPK1 (0.51)	CTSSCTSKL3MBTL1KDM4EALDH1A1
	SCHEMBL15630751	0.78	AKT1 (0.41)	CHRNB2CHRNB4CHRNA3CHRNA4CTSS
	SCHEMBL5698049	0.78	CHRNB2 (0.54)	CHRNB2CHRNB4CHRNA3CHRNA4OPRM1
	SCHEMBL16689325	0.78	CHRNB2 (0.54)	CHRNB2CHRNB4CHRNA3CHRNA4OPRM1
	SCHEMBL2886224	0.78	GPBAR1 (0.49)	L3MBTL1KDM4EGAAALDH1A1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (17 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.