SCHEMBL12788231

SCHEMBL12788231

Fc1cc(C(F)(F)F)cc(Cl)n1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TACR1 P25103 6/20 0.37
SLC6A4 P31645 6/20 0.37
KCNH2 Q12809 6/20 0.37
GABRB3 P28472 4/20 0.36
GABRA2 P47869 3/20 0.36
GABRB2 P47870 3/20 0.36
CYP3A4 P08684 2/20 0.35
ALDH1A1 P00352 1/20 0.35
HPGD P15428 1/20 0.35
ALOX15 P16050 1/20 0.35
TSHR P16473 1/20 0.35
HIF1A Q16665 1/20 0.35
TXNRD1 Q16881 1/20 0.35
TXNRD3 Q86VQ6 1/20 0.35
TXNRD2 Q9NNW7 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
NFKB1 P19838 4/20 0.35
NFKB2 Q00653 4/20 0.35
RELA Q04206 4/20 0.35
SMN1; SMN2 Q16637 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL561772 0.85 ALDH1A1 (0.40) TACR1SLC6A4KCNH2GABRB3GABRA2
SCHEMBL9787177 0.83 CES2 (0.39) CYP3A4ALDH1A1HPGDALOX15TSHR
SCHEMBL22956024 0.80 GABRB2 (0.34) KCNH2GABRA2GABRB2
SCHEMBL4703323 0.77 ADORA2A (0.39) TACR1SLC6A4KCNH2GABRA2GABRB2
SCHEMBL23181498 0.76 GABRB3 (0.36) TACR1SLC6A4KCNH2GABRB3GABRA2
SCHEMBL11109288 0.76 S1PR1 (0.36) GABRA2GABRB2CYP3A4ALDH1A1HPGD
SCHEMBL29560454 0.76 NOS3 (0.45) GABRB3GABRA2GABRB2CYP3A4ALDH1A1
SCHEMBL29659055 0.76 HSP90AA1 (0.39) GABRB3GABRA2GABRB2SMN1; SMN2NPC1
SCHEMBL562878 0.76 HSP90AA1 (0.39) GABRB3GABRA2GABRB2SMN1; SMN2NPC1
SCHEMBL29256257 0.76 XPO1 (0.36) TACR1SLC6A4KCNH2GABRB3GABRA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119330876-A Preparation method of Flupyroxystrobin 山东京博农化科技股份有限公司 2025-01-21 CN disclosed
US-11882828-B2 Mosquito vector control compositions, methods and products utilizing same SYNGENTA PARTICIPATIONS AG (CH) 2024-01-30 US disclosed
EP-3814332-B1 PESTICIDALLY ACTIVE AZOLE-AMIDE COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2023-06-07 EP disclosed
US-20230123440-A1 MOSQUITO VECTOR CONTROL COMPOSITIONS, METHODS AND PRODUCTS UTILIZING SAME SYNGENTA PARTICIPATIONS AG (CH) 2023-04-20 US disclosed
EP-3814332-A1 PESTICIDALLY ACTIVE AZOLE-AMIDE COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2021-05-05 EP disclosed
CN-112351978-A Pesticidally active azole-amide compounds 先正达参股股份有限公司 2021-02-09 CN disclosed
WO-2020002563-A1 PESTICIDALLY ACTIVE AZOLE-AMIDE COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2020-01-02 WO disclosed
US-20190082687-A1 MOSQUITO VECTOR CONTROL COMPOSITIONS, METHODS AND PRODUCTS UTILIZING SAME SYNGENTA PARTICIPATIONS AG (CH) 2019-03-21 US disclosed
EP-3302056-A1 MOSQUITO VECTOR CONTROL COMPOSITIONS, METHODS AND PRODUCTS UTILIZING SAME Syngenta Participations AG (CH) 2018-04-11 EP disclosed
WO-2016193267-A1 MOSQUITO VECTOR CONTROL COMPOSITIONS, METHODS AND PRODUCTS UTILIZING SAME SYNGENTA PARTICIPATIONS AG (CH) 2016-12-08 WO disclosed
US-8895568-B2 Compositions comprising substituted pteridines as agrochemicals DOW AGROSCIENCES, LLC. (US) 2014-11-25 US disclosed
US-8895568-B2 Compositions comprising substituted pteridines as agrochemicals DOW AGROSCIENCES, LLC. (US) 2014-11-25 US disclosed
US-20130252960-A1 PTERIDINES AND THEIR USE AS AGROCHEMICALS DOW AGROSCIENCES LLC (US) 2013-09-26 US disclosed
US-20130252960-A1 PTERIDINES AND THEIR USE AS AGROCHEMICALS DOW AGROSCIENCES LLC (US) 2013-09-26 US disclosed
US-8461164-B2 Pteridines and their use as agrochemicals DOW AGROSCIENCES, LLC. (US) 2013-06-11 US disclosed
US-8461164-B2 Pteridines and their use as agrochemicals DOW AGROSCIENCES, LLC. (US) 2013-06-11 US disclosed
US-20110054173-A1 PTERIDINES AND THEIR USE AS AGROCHEMICALS DOW AGROSCIENCES LLC (US) 2011-03-03 US disclosed
US-20110054173-A1 PTERIDINES AND THEIR USE AS AGROCHEMICALS DOW AGROSCIENCES LLC (US) 2011-03-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230123440-A1 MOSQUITO VECTOR CONTROL COMPOSITIONS, METHODS AND PRODUCTS UTILIZING SAME DDT, MLEC, MSMO1 TACR1 3161/4885SLC6A4 3845/4885KCNH2 3172/4885
US-20190082687-A1 MOSQUITO VECTOR CONTROL COMPOSITIONS, METHODS AND PRODUCTS UTILIZING SAME DDT, MLEC, MSMO1 TACR1 3161/4885SLC6A4 3845/4885KCNH2 3172/4885
US-20130252960-A1 PTERIDINES AND THEIR USE AS AGROCHEMICALS CBR3, CBR1, AKR1C4 TACR1 3317/4885SLC6A4 1779/4885KCNH2 96/4885
US-11882828-B2 Mosquito vector control compositions, methods and products utilizing same DDT, MLEC, MSMO1 TACR1 3161/4885SLC6A4 3845/4885KCNH2 3172/4885
US-20110054173-A1 PTERIDINES AND THEIR USE AS AGROCHEMICALS PIR, PFAS, PNPO TACR1 3198/4885SLC6A4 1344/4885KCNH2 3479/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.