Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of (R)-3-Hydroxybutanoate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| (R)-3-Hydroxybutanoate SCHEMBL19460661 | 1.00 | — | — | |
| (R)-3-Hydroxybutanoate SCHEMBL22321684 | 1.00 | — | — | |
| (R)-3-Hydroxybutanoate SCHEMBL21775465 | 0.97 | — | — | |
| (R)-3-Hydroxybutanoate SCHEMBL19459352 | 0.94 | CA2 (0.57) | — | |
| (R)-3-Hydroxybutanoate SCHEMBL1330790 | 0.94 | — | — | |
| (R)-3-Hydroxybutanoate SCHEMBL22321678 | 0.94 | CA2 (0.57) | — | |
| (R)-3-Hydroxybutanoate SCHEMBL20518506 | 0.94 | CA2 (0.57) | — | |
| (R)-3-Hydroxybutanoate SCHEMBL7209004 | 0.94 | CA2 (0.57) | — | |
| (R)-3-Hydroxybutanoate SCHEMBL194589 | 0.94 | — | — | |
| (R)-3-Hydroxybutanoate SCHEMBL21060562 | 0.94 | CA2 (0.57) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 325 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260130876-A1 | ADMINISTRATION OF BETA-HYDROXYBUTYRATE AND RELATED COMPOUNDS IN HUMANS | AXCESS GLOBAL SCIENCES LLC (US) | 2026-05-14 | — | — | US | claimed |
| US-12551455-B2 | Compositions and methods for keto stacking with beta-hydroxybutyrate and acetoacetate | AXCESS GLOBAL SCIENCES, LLC (US) | 2026-02-17 | — | — | US | claimed |
| US-12496283-B2 | Administration of R-beta-hydroxybutyrate and related compounds in humans | AXCESS GLOBAL SCIENCES, LLC (US) | 2025-12-16 | — | — | US | claimed |
| US-12396974-B2 | Ketone ester as a therapeutic treatment of Covid-19 and related viral infections | KetoneAid (US) | 2025-08-26 | — | — | US | claimed |
| CN-119968132-A | Acid and salt compound and preparation method thereof | 南京纽邦生物科技有限公司 | 2025-05-09 | — | — | CN | claimed |
| US-12251362-B2 | Administration of R-beta-hydroxybutyrate and related compounds in humans | AXCESS GLOBAL SCIENCES, LLC (US) | 2025-03-18 | — | — | US | claimed |
| US-20250032434-A1 | ADMINISTRATION OF R-BETA-HYDROXYBUTYRATE AND RELATED COMPOUNDS IN HUMANS | AXCESS GLOBAL SCIENCES, LLC | 2025-01-30 | — | — | US | claimed |
| US-12171735-B2 | Administration of butyrate, beta-hydroxybutyrate, cannabidiol, and related compounds in humans | AXCESS GLOBAL SCIENCES, LLC (US) | 2024-12-24 | — | — | US | claimed |
| US-12167993-B2 | Non-vasoconstricting energy-promoting compositions containing ketone bodies | AXCESS GLOBAL SCIENCES, LLC (US) | 2024-12-17 | — | — | US | claimed |
| CN-118908825-A | Method for synthesizing 3-hydroxy ethyl butyrate | 东莞理工学院 | 2024-11-08 | — | — | CN | claimed |
| US-20170258745-A1 | MIXED SALT COMPOSITIONS FOR PRODUCING ELEVATED AND SUSTAINED KETOSIS | AXCESS GLOBAL SCIENCES, LLC | 2017-09-14 | — | — | US | claimed |
| US-9675577-B2 | Compositions and methods for producing elevated and sustained ketosis | UNIVERSITY OF SOUTH FLORIDA (US) | 2017-06-13 | — | — | US | claimed |
| US-20160067207-A1 | COMPOSITIONS AND METHODS FOR PRODUCING ELEVATED AND SUSTAINED KETOSIS | UNIVERSITY OF SOUTH FLORIDA (US) | 2016-03-10 | — | — | US | claimed |
| EP-2976073-A1 | COMPOSITIONS AND METHODS FOR PRODUCING ELEVATED AND SUSTAINED KETOSIS | University Of South Florida (US) | 2016-01-27 | — | — | EP | claimed |
| US-9138420-B2 | Compositions and methods for producing elevated and sustained ketosis | UNIVERSITY OF SOUTH FLORIDA (US) | 2015-09-22 | — | — | US | claimed |
| US-20140350105-A1 | COMPOSITIONS AND METHODS FOR PRODUCING ELEVATED AND SUSTAINED KETOSIS | UNIVERSITY OF SOUTH FLORIDA (US) | 2014-11-27 | — | — | US | claimed |
| WO-2014153416-A1 | COMPOSITIONS AND METHODS FOR PRODUCING ELEVATED AND SUSTAINED KETOSIS | UNIVERSITY OF SOUTH FLORIDA (US) | 2014-09-25 | — | — | WO | claimed |
| EP-1466649-B1 | Pharmaceutical composition containing artificial oxygen carrier | NIPRO CORP (JP) | 2008-08-13 | — | — | EP | claimed |
| US-6613356-B1 | Medication for weight loss by means of appetite suppression and a method for administering this medication to humans and other mammals. The medication comprises potassium butyrate or closely related chemical compounds, together with chemicals | AXCESS GLOBAL SCIENCES, LLC | 2003-09-02 | — | — | US | claimed |
| EP-0355453-A2 | Use of 3-hydroxybutyric acid as an energy source | KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1990-02-28 | — | — | EP | claimed |