Water

Water

SCHEMBL1286428

O.c1ccc2c(c1)O2.c1ccc2c(c1)O2

nearest known ligand 0.53

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO

The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX5 known ✓ P09917 1/20 0.53
MAOA P21397 2/20 0.53
MAOB P27338 2/20 0.53
AHR P35869 4/20 0.52
ABCG2 Q9UNQ0 1/20 0.44
ITGB2 P05107 1/20 0.44
ICAM1 P05362 1/20 0.44
ITGAL P20701 1/20 0.44
ATM Q13315 2/20 0.42
TRPA1 O75762 1/20 0.42
KDM4E B2RXH2 1/20 0.42
MAPK1 P28482 1/20 0.42
GAA P10253 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39
CYP1A2 P05177 1/20 0.39
CYP2D6 P10635 1/20 0.39
P2RX4 Q99571 1/20 0.39
LMNA P02545 1/20 0.38
CRHBP P24387 1/20 0.38
HTT P42858 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Water SCHEMBL12971464 1.00
SCHEMBL15613 0.96
SCHEMBL29724179 0.96 MAOA (0.56) MAOAMAOBALOX5AHRABCG2
SCHEMBL8668546 0.96 MAOA (0.56) MAOAMAOBALOX5AHRABCG2
SCHEMBL29383458 0.96 MAOA (0.56) MAOAMAOBALOX5AHRABCG2
SCHEMBL125113 0.96 MAOA (0.56) MAOAMAOBALOX5AHRABCG2
SCHEMBL8671027 0.96 MAOA (0.56) MAOAMAOBALOX5AHRABCG2
SCHEMBL3102452 0.96 MAOA (0.56) MAOAMAOBALOX5AHRABCG2
Hydrochloric Acid SCHEMBL7270002 0.92 MAOA (0.53) MAOAMAOBALOX5AHRABCG2
Hydrochloric Acid SCHEMBL7263461 0.92 MAOA (0.53) MAOAMAOBALOX5AHRABCG2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 97 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11867344-B2 Composite insulation system NELSON GLOBAL PRODUCTS, INC. (US) 2024-01-09 US claimed
EP-3443254-B1 COMPOSITE INSULATION SYSTEM SAPREX LLC (US) 2023-12-13 EP claimed
US-20190329486-A1 COMPOSITE INSULATION SYSTEM TRU-FLEX, LLC 2019-10-31 US claimed
EP-3541601-A1 COMPOSITE INSULATION SYSTEM Saprex, LLC (US) 2019-09-25 EP claimed
US-20190120419-A1 COMPOSITE INSULATION SYSTEM SAPREX, LLC (US) 2019-04-25 US claimed
EP-3443254-A1 COMPOSITE INSULATION SYSTEM Saprex, LLC (US) 2019-02-20 EP claimed
WO-2017181197-A1 COMPOSITE INSULATION SYSTEM SAPREX, LLC (US) 2017-10-19 WO claimed
CN-103619909-B The manufacture method of polyphenyl ether ether ketone TORAY INDUSTRIES, INC. (JP) 2016-05-11 CN claimed
CN-103814019-A Method for recovering cyclic polyphenylene ether ether ketone composition and method for producing polyphenylene ether ether ketone using same TORAY INDUSTRIES 2014-05-21 CN claimed
CN-103619909-A Method for producing polyphenylene ether ether ketone TORAY INDUSTRIES 2014-03-05 CN claimed
CN-102652133-B Cyclic polyphenylene ether ether ketone composition and method for producing the same TORAY INDUSTRIES 2013-12-04 CN claimed
EP-0513812-B1 Thermoplastic resin composition MITSUBISHI CHEM CORP (JP) 1996-03-27 EP claimed
EP-0513812-A2 Thermoplastic resin composition MITSUBISHI CHEMICAL CORPORATION (JP) 1992-11-19 EP claimed
WO-1991014248-A1 CRYSTALLINE POLYOLEFIN GRAFT COPOLYMERS EXXON CHEMICAL PATENTS INC. (US) 1991-09-19 WO claimed
US-4152495-A Foamed thermoplastic resin composition containing multiple stage polymeric modifiers ROHM AND HAAS COMPANY (US) 1979-05-01 US claimed
JP-6166797-A None JP disclosed
US-20240142042-A1 EXHAUST INSULATION SYSTEM NELSON GLOBAL PRODUCTS, INC. (US) 2024-05-02 US disclosed
EP-0040665-A1 Flame retardant polyphenylene oxide composition FMC Corporation (US) 1981-12-02 EP disclosed
US-4287119-A CONTAINING POLYPHENYLENE OXIDE FMC CORPORATION (US) 1981-09-01 US disclosed
US-4152495-A Foamed thermoplastic resin composition containing multiple stage polymeric modifiers ROHM AND HAAS COMPANY (US) 1979-05-01 US disclosed