SCHEMBL12873290

SCHEMBL12873290

CC1(C)C(=O)N(c2ccc(C#N)nc2)C(=O)N1Cc1ccccc1Oc1ccccc1

nearest known ligand 0.43

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
TAS2R8 Q9NYW2 9/20 0.43
IGF1R P08069 1/20 0.38
FAAH O00519 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1191749 0.85 SLC6A4 (0.45) TAS2R8IGF1RFAAH
SCHEMBL8021401 0.85 TAS2R8 (0.46) TAS2R8IGF1RFAAH
SCHEMBL8029509 0.83 TAS2R8 (0.41) TAS2R8IGF1R
SCHEMBL3527140 0.83 IGF1R (0.41) TAS2R8IGF1R
SCHEMBL8023307 0.82 TAS2R8 (0.47) TAS2R8IGF1RFAAH
SCHEMBL8001620 0.82 LMNA (0.46) TAS2R8IGF1RFAAH
SCHEMBL12873224 0.82 TAS2R8 (0.48) TAS2R8IGF1RFAAH
SCHEMBL12873200 0.82 TAS2R8 (0.41) TAS2R8IGF1RFAAH
SCHEMBL8020844 0.81 TAS2R8 (0.46) TAS2R8IGF1RFAAH
SCHEMBL13254880 0.81 IGF1R (0.43) TAS2R8IGF1R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110046185-A1 Arylchalcogenoarylalkyl-substituted imidazolidine-2,4-diones, process for preparation thereof, medicaments comprising these compounds and use thereof SANOFI-AVENTIS (FR) 2011-02-24 US disclosed
US-20110046185-A1 Arylchalcogenoarylalkyl-substituted imidazolidine-2,4-diones, process for preparation thereof, medicaments comprising these compounds and use thereof SANOFI-AVENTIS (FR) 2011-02-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110046185-A1 Arylchalcogenoarylalkyl-substituted imidazolidine-2,4-diones, process for preparation thereof, medicaments comprising these compounds and use thereof PGC, LIPC, CEL TAS2R8 318/4885IGF1R 645/4885FAAH 1395/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.