Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 5/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.41 |
| ▸ | CETP | P11597 | 5/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.38 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 2/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | NMT1 | P30419 | 1/20 | 0.31 |
| ▸ | PDE9A | O76083 | 1/20 | 0.31 |
| ▸ | PDE1A | P54750 | 1/20 | 0.31 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.31 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.31 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.31 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.31 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.31 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.31 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.31 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13061125 | 0.93 | SLC6A4 (0.41) | SLC6A4SLC6A2CETPSLC6A3LNPEP | |
| SCHEMBL13005616 | 0.88 | BCHE (0.40) | SLC6A4SLC6A2CETPSLC6A3CYP2D6 | |
| SCHEMBL13005509 | 0.85 | SLC6A4 (0.47) | SLC6A4SLC6A2CETPSLC6A3KCNH2 | |
| SCHEMBL13005504 | 0.83 | ALDH1A1 (0.36) | SLC6A2CETPSLC6A3GRIN2DGRIN3B | |
| SCHEMBL13005518 | 0.81 | CETP (0.40) | SLC6A4SLC6A2CETPSLC6A3KCNH2 | |
| SCHEMBL13005520 | 0.81 | LMNA (0.37) | SLC6A4SLC6A2CETPSLC6A3 | |
| SCHEMBL13005507 | 0.81 | TAAR1 (0.34) | CETPGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL13005500 | 0.81 | GABRA1 (0.39) | CETPGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL13005522 | 0.81 | CETP (0.36) | CETPGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL13061124 | 0.80 | ACHE (0.40) | SLC6A4SLC6A2SLC6A3CYP2D6HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7851637-B2 | Compounds and methods for inhibiting the interaction of BCL proteins with binding partners | INFINITY PHARMACEUTICALS, INC. (US) | 2010-12-14 | — | — | US | disclosed |
| US-7851637-B2 | Compounds and methods for inhibiting the interaction of BCL proteins with binding partners | INFINITY PHARMACEUTICALS, INC. (US) | 2010-12-14 | — | — | US | disclosed |