Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.56 |
| ▸ | RAB9A | P51151 | 4/20 | 0.56 |
| ▸ | CASP3 | P42574 | 1/20 | 0.56 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 11/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | AIMP2 | Q13155 | 1/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13044632 | 0.88 | MAPT (0.54) | NPC1RAB9ACASP3SENP7MAPT | |
| SCHEMBL13044605 | 0.84 | RAB9A (0.76) | NPC1RAB9ACASP3SENP7MAPT | |
| SCHEMBL13044596 | 0.81 | MAPT (0.54) | NPC1RAB9AMAPTALDH1A1LMNA | |
| SCHEMBL13044622 | 0.80 | RAB9A (0.72) | NPC1RAB9ACASP3SENP7MAPT | |
| SCHEMBL13043206 | 0.79 | MAPT (0.50) | NPC1RAB9ACASP3SENP7MAPK1 | |
| SCHEMBL13043227 | 0.79 | MAPT (0.52) | NPC1RAB9ACASP3SENP7MAPK1 | |
| SCHEMBL13044620 | 0.78 | RAB9A (0.62) | NPC1RAB9ACASP3SENP7TP53 | |
| SCHEMBL1557644 | 0.78 | ALDH1A1 (0.69) | RAB9AMAPTALDH1A1LMNAMEN1 | |
| SCHEMBL13044616 | 0.76 | RAB9A (0.68) | NPC1RAB9ACASP3SENP7MAPT | |
| SCHEMBL3805482 | 0.75 | RAB9A (0.67) | NPC1RAB9ACASP3SENP7TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010139982-A1 | INDOLE DERIVATIVES FOR THE STIMULATION OF STEM CELL PROLIFERATION | THE UNIVERSITY OF SHEFFIELD (GB) | 2010-12-09 | — | — | WO | disclosed |