Sugi Predict

Sugi Predict / Compounds / Glutamine

Glutamine

Glutamine

SCHEMBL1304983

C[C@@H](OC(=O)[C@@H]1CCCN1)[C@H](N)C(=O)O.NC(=O)CC[C@H](N)C(=O)O

nearest known ligand 0.43

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 2/20 0.43
▸ ALOX15 P16050 1/20 0.43
▸ BLM P54132 1/20 0.43
▸ PMP22 Q01453 1/20 0.43
▸ NOS2 P35228 2/20 0.33
▸ NOS3 P29474 1/20 0.33
▸ NOS1 P29475 1/20 0.33
▸ DPP7 Q9UHL4 1/20 0.33
▸ DPP4 P27487 1/20 0.33
▸ DPP8 Q6V1X1 1/20 0.33
▸ DPP9 Q86TI2 1/20 0.33
▸ CYP1A2 P05177 2/20 0.32
▸ GRM8 O00222 1/20 0.32
▸ GRM6 O15303 1/20 0.32
▸ GRIN2D O15399 1/20 0.32
▸ GRIN3B O60391 1/20 0.32
▸ GSR P00390 1/20 0.32
▸ GRIK1 P39086 1/20 0.32
▸ GRM5 P41594 1/20 0.32
▸ GRIA1 P42261 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1887227 0.87 NOS2 (0.40) NOS2NOS3NOS1DPP7DPP4
Glycine SCHEMBL10428555 0.86 ALOX15 (0.30) KMT2AALOX15BLMPMP22
Leucine SCHEMBL6463328 0.85 SLC7A5 (0.44) NOS2NOS3NOS1DPP7DPP4
Glutamine SCHEMBL4667538 0.82 KMT2A (0.46) KMT2AALOX15BLMPMP22NOS2
Glutamine SCHEMBL27660739 0.82 KMT2A (0.46) KMT2AALOX15BLMPMP22NOS2
Glutamine SCHEMBL27639978 0.81 KMT2A (0.45) KMT2AALOX15BLMPMP22NOS2
Glutamine SCHEMBL1304984 0.81 KMT2A (0.45) KMT2AALOX15BLMPMP22NOS2
Glutamine SCHEMBL17782941 0.81 ALOX15 (0.50) KMT2AALOX15BLMPMP22NOS2
Glutamine SCHEMBL17907437 0.81 ALOX15 (0.50) KMT2AALOX15BLMPMP22NOS2
Glutamine SCHEMBL6853199 0.81 ALOX15 (0.44) KMT2AALOX15BLMPMP22NOS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2478766-A2 Targeting host proteinases as a therapeutic strategy against viral and bacterial pathogens Burnham Institute for Medical Research (US) 2012-07-25 — — EP disclosed
US-8053553-B2 Targeting host proteinases as a therapeutic strategy against viral and bacterial pathogens SOCPRA SCIENCES SANTE ET HUMAINES (CA) 2011-11-08 — — US disclosed
EP-2155894-A2 TARGETING HOST PROTEINASES AS A THERAPEUTIC STRATEGY AGAINST VIRAL AND BACTERIAL PATHOGENS Burnham Institute for Medical Research (US) 2010-02-24 — — EP disclosed
WO-2009023306-A2 TARGETING HOST PROTEINASES AS A THERAPEUTIC STRATEGY AGAINST VIRAL AND BACTERIAL PATHOGENS BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) 2009-02-19 — — WO disclosed
US-20090029924-A1 Targeting Host Proteinases as a Therapeutic Strategy Against Viral and Bacterial Pathogens NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR 2009-01-29 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090029924-A1 Targeting Host Proteinases as a Therapeutic Strategy Against Viral and Bacterial Pathogens SERPINB1, TMPRSS15, HPN KMT2A 4681/4885ALOX15 1313/4885BLM 1757/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.