Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | NAAA | Q02083 | 2/20 | 0.54 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12404689 | 1.00 | ALDH1A1 (0.57) | ALDH1A1GAATSHRNAAAEPHX1 | |
| SCHEMBL753991 | 1.00 | ALDH1A1 (0.57) | ALDH1A1GAATSHRNAAAEPHX1 | |
| SCHEMBL18661873 | 0.92 | NAAA (0.66) | NAAAEPHX1 | |
| SCHEMBL18661487 | 0.92 | NAAA (0.66) | NAAAEPHX1 | |
| SCHEMBL28779434 | 0.89 | ALDH1A1 (0.50) | ALDH1A1GAATSHRNAAA | |
| SCHEMBL15373744 | 0.87 | ALDH1A1 (0.47) | ALDH1A1GAATSHRNAAA | |
| SCHEMBL6060180 | 0.86 | MEN1 (0.63) | ALDH1A1GAATSHRNAAA | |
| SCHEMBL7511180 | 0.86 | MEN1 (0.63) | ALDH1A1GAATSHRNAAA | |
| SCHEMBL3169636 | 0.86 | MEN1 (0.63) | ALDH1A1GAATSHRNAAA | |
| SCHEMBL7513937 | 0.84 | MEN1 (0.55) | ALDH1A1GAATSHRNAAAEPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10363237-B2 | Compositions and methods of inhibiting N-acylethanolamine-hydrolyzing acid amidase | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2019-07-30 | — | — | US | disclosed |
| US-20160256432-A1 | COMPOSITIONS AND METHODS OF INHIBITING N-ACYLETHANOLAMINE-HYDROLYZING ACID AMIDASE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2016-09-08 | — | — | US | disclosed |
| EP-2200564-B1 | COMPOSITIONS AND METHODS OF INHIBITING N-ACYLETHANOLAMINE-HYDROLYZING ACID AMIDASE | UNIV CALIFORNIA (US) | 2016-05-04 | — | — | EP | disclosed |
| US-9321743-B2 | Compositions and methods of inhibiting N-acylethanolamine-hydrolyzing acid amidase | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-04-26 | — | — | US | disclosed |
| US-20100311711-A1 | Inhibitors of NAAA and Methods Thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-12-09 | — | — | US | disclosed |
| US-20090215985-A1 | DIFFERENTIALLY PROTECTED ORTHOGONAL LANTHIONINE TECHNOLOGY | ORAGENICS, INC. | 2009-08-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10363237-B2 | Compositions and methods of inhibiting N-acylethanolamine-hydrolyzing acid amidase | NAAA, NAPEPLD, FAAH | ALDH1A1 2494/4885GAA 300/4885TSHR 3903/4885 |
| US-20090215985-A1 | DIFFERENTIALLY PROTECTED ORTHOGONAL LANTHIONINE TECHNOLOGY | VIP, LGMN, LNPEP | ALDH1A1 4711/4885GAA 3542/4885TSHR 1232/4885 |
| US-20100311711-A1 | Inhibitors of NAAA and Methods Thereof | NAAA, NAA50, FAAH | ALDH1A1 1546/4885GAA 236/4885TSHR 3897/4885 |
| US-20160256432-A1 | COMPOSITIONS AND METHODS OF INHIBITING N-ACYLETHANOLAMINE-HYDROLYZING ACID AMIDASE | NAAA, NAPEPLD, FAAH | ALDH1A1 2494/4885GAA 300/4885TSHR 3903/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.