Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | MEN1 | O00255 | 6/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.40 |
| ▸ | NQO2 | P16083 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | CTSB | P07858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3766046 | 1.00 | MAPT (0.47) | MAPTKMT2AALDH1A1MEN1NPSR1 | |
| SCHEMBL15521739 | 0.89 | MAPT (0.46) | MAPTKMT2AALDH1A1MEN1NPSR1 | |
| SCHEMBL16782911 | 0.89 | MAPT (0.46) | MAPTKMT2AALDH1A1MEN1NPSR1 | |
| SCHEMBL23675071 | 0.86 | MAPT (0.41) | MAPTKMT2AALDH1A1MEN1NPSR1 | |
| SCHEMBL23675070 | 0.86 | MAPT (0.41) | MAPTKMT2AALDH1A1MEN1NPSR1 | |
| SCHEMBL25391810 | 0.85 | MAPT (0.43) | MAPTKMT2AALDH1A1MEN1NPSR1 | |
| SCHEMBL25391816 | 0.85 | MAPT (0.43) | MAPTKMT2AALDH1A1MEN1NPSR1 | |
| SCHEMBL16690277 | 0.80 | MAPT (0.48) | MAPTKMT2AALDH1A1MEN1NPSR1 | |
| SCHEMBL20862224 | 0.80 | MAPT (0.47) | MAPTKMT2AALDH1A1MEN1NPSR1 | |
| SCHEMBL5518656 | 0.76 | ALDH1A1 (0.42) | MAPTKMT2AALDH1A1MEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11492359-B2 | Near-infrared nerve-sparing fluorophores | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2022-11-08 | — | — | US | disclosed |
| US-20210317137-A1 | NEAR-INFRARED NERVE-SPARING FLUOROPHORES | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2021-10-14 | — | — | US | disclosed |
| US-20210236657-A1 | NERVE-SPECIFIC FLUOROPHORE FORMULATIONS FOR DIRECT AND SYSTEMIC ADMINISTRATION | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2021-08-05 | — | — | US | disclosed |
| US-9796730-B2 | Halogenated benzoxazines and their use | EBERHARD KARLS UNIVERSITAET TUEBINGEN MEDIZINISCHE FAKULTAET (DE) | 2017-10-24 | — | — | US | disclosed |
| US-9796730-B2 | Halogenated benzoxazines and their use | EBERHARD KARLS UNIVERSITAET TUEBINGEN MEDIZINISCHE FAKULTAET (DE) | 2017-10-24 | — | — | US | disclosed |
| US-9796730-B2 | Halogenated benzoxazines and their use | EBERHARD KARLS UNIVERSITAET TUEBINGEN MEDIZINISCHE FAKULTAET (DE) | 2017-10-24 | — | — | US | disclosed |
| US-20150166572-A1 | HALOGENATED BENZOXAZINES AND THEIR USE | EBERHARD KARLS UNIVERSITAET TUEBINGEN MEDIZINISCHE FAKULTAET (DE) | 2015-06-18 | — | — | US | disclosed |
| US-20150166572-A1 | HALOGENATED BENZOXAZINES AND THEIR USE | EBERHARD KARLS UNIVERSITAET TUEBINGEN MEDIZINISCHE FAKULTAET (DE) | 2015-06-18 | — | — | US | disclosed |
| US-20150166572-A1 | HALOGENATED BENZOXAZINES AND THEIR USE | EBERHARD KARLS UNIVERSITAET TUEBINGEN MEDIZINISCHE FAKULTAET (DE) | 2015-06-18 | — | — | US | disclosed |
| US-8679776-B2 | Activatable dyes | UNIVERSITY OF MASSACHUSETTS (US) | 2014-03-25 | — | — | US | disclosed |
| WO-2014032732-A1 | HALOGENATED BENZOXAZINES AND USE THEREOF | EBERHARD KARLS UNIVERSITÄT TÜBINGEN MEDIZINISCHE FAKULTÄT (DE) | 2014-03-06 | — | — | WO | disclosed |
| US-20100297684-A1 | ACTIVATIBLE DYES | UNIVERSITY OF MASSACHUSETTS | 2010-11-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11492359-B2 | Near-infrared nerve-sparing fluorophores | NTRK1, PMP22, GAP43 | MAPT 636/4885KMT2A 2855/4885ALDH1A1 813/4885 |
| US-20210236657-A1 | NERVE-SPECIFIC FLUOROPHORE FORMULATIONS FOR DIRECT AND SYSTEMIC ADMINISTRATION | PFAS, NPFFR2, NPFFR1 | MAPT 1093/4885KMT2A 3779/4885ALDH1A1 1305/4885 |
| US-20100297684-A1 | ACTIVATIBLE DYES | IK, MB, HMBS | MAPT 3995/4885KMT2A 2859/4885ALDH1A1 856/4885 |
| US-20210317137-A1 | NEAR-INFRARED NERVE-SPARING FLUOROPHORES | NTRK1, NGF, SMN1; SMN2 | MAPT 803/4885KMT2A 4578/4885ALDH1A1 822/4885 |
| US-20150166572-A1 | HALOGENATED BENZOXAZINES AND THEIR USE | XDH, BAZ1A, CYP4Z1 | MAPT 99/4885KMT2A 992/4885ALDH1A1 819/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.