Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CES2 | O00748 | 2/20 | 0.39 |
| ▸ | CES1 | P23141 | 2/20 | 0.39 |
| ▸ | HRH1 | P35367 | 4/20 | 0.38 |
| ▸ | HTR2A | P28223 | 3/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | CCR3 | P51677 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22042217 | 0.89 | HRH1 (0.44) | TRPA1CES2CES1HRH1HTR2A | |
| SCHEMBL8037602 | 0.85 | TRPA1 (0.48) | TRPA1LMNAALDH1A1CES2CES1 | |
| SCHEMBL5410942 | 0.80 | HRH1 (0.58) | TRPA1LMNAALDH1A1HSD17B10HRH1 | |
| SCHEMBL22042211 | 0.79 | HRH1 (0.46) | TRPA1CES2CES1HRH1HTR2A | |
| SCHEMBL6203441 | 0.79 | HTR2A (0.42) | TRPA1CES2CES1HRH1HTR2A | |
| SCHEMBL4459353 | 0.79 | SIGMAR1 (0.44) | LMNAALDH1A1HTR2ASIGMAR1KDM4E | |
| SCHEMBL8141988 | 0.79 | BRD4 (0.35) | LMNASLC6A2SLC6A4SLC6A3L3MBTL1 | |
| SCHEMBL1308572 | 0.78 | RIPK1 (0.53) | TRPA1LMNAALDH1A1HSD17B10KDM4E | |
| SCHEMBL9579891 | 0.78 | RIPK1 (0.53) | TRPA1LMNAALDH1A1HSD17B10KDM4E | |
| SCHEMBL5412370 | 0.78 | HRH1 (0.56) | TRPA1HRH1HTR2ASIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2244575-B1 | ANGIOTENSIN II RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME (US) | 2013-07-17 | — | — | EP | disclosed |
| US-8053455-B2 | Angiotensin II receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2011-11-08 | — | — | US | disclosed |
| US-20110201621-A1 | ANGIOTENSIN II RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2011-08-18 | — | — | US | disclosed |
| US-7947664-B2 | Angiotensin II receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2011-05-24 | — | — | US | disclosed |
| US-20100292192-A1 | ANGIOTENSIN II RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. | 2010-11-18 | — | — | US | disclosed |
| EP-2244575-A1 | ANGIOTENSIN II RECEPTOR ANTAGONISTS | Merck Sharp & Dohme Corp. (US) | 2010-11-03 | — | — | EP | disclosed |
| WO-2009094242-A1 | ANGIOTENSIN II RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2009-07-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110201621-A1 | ANGIOTENSIN II RECEPTOR ANTAGONISTS | AGTR1, AGTR2, REN | TRPA1 1996/4885LMNA 2956/4885ALDH1A1 4024/4885 |
| US-20100292192-A1 | ANGIOTENSIN II RECEPTOR ANTAGONISTS | AGTR1, AGTR2, REN | TRPA1 1889/4885LMNA 3016/4885ALDH1A1 4026/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.