SCHEMBL13085517

SCHEMBL13085517

CNC(=O)c1cc(Cl)cc(C)c1NC(=O)c1cc(Cn2nnnc2C(F)(F)F)nn1-c1ccccc1

nearest known ligand 0.45

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
NTRK1 P04629 5/20 0.40
KMT2A Q03164 4/20 0.37
MEN1 O00255 2/20 0.36
MAPT P10636 2/20 0.35
ALDH1A1 P00352 1/20 0.35
LMNA P02545 1/20 0.35
DHODH Q02127 2/20 0.35
RIPK1 Q13546 1/20 0.34
NPY5R Q15761 1/20 0.34
TSHR P16473 1/20 0.34
CYP2C9 P11712 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13085510 0.90 NTRK1 (0.34) NTRK1DHODHRIPK1NPY5R
SCHEMBL13085380 0.88 ALDH1A1 (0.36) NTRK1ALDH1A1
SCHEMBL13085481 0.88 L3MBTL1 (0.38) NTRK1ALDH1A1CYP2C9
SCHEMBL684736 0.88 NTRK1 (0.33) NTRK1ALDH1A1LMNADHODH
SCHEMBL13085417 0.86 NTRK1 (0.32) NTRK1
SCHEMBL13085409 0.85 KMT2A (0.37) NTRK1KMT2AMEN1MAPTALDH1A1
SCHEMBL13085565 0.82 ALDH1A1 (0.35) NTRK1KMT2AMEN1ALDH1A1LMNA
SCHEMBL10076317 0.82 SLC2A1 (0.36) NTRK1KMT2AMEN1
SCHEMBL685553 0.82 NTRK1 (0.32) NTRK1KMT2AMEN1CYP2C9
SCHEMBL687025 0.82 DHODH (0.32) NTRK1DHODH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8324390-B2 Tetrazole-substituted anthranilamides as pesticides BAYER CROPSCIENCE AG (DE) 2012-12-04 US disclosed
US-8324390-B2 Tetrazole-substituted anthranilamides as pesticides BAYER CROPSCIENCE AG (DE) 2012-12-04 US disclosed
US-20100256195-A1 Tetrazole-substituted anthranilamides as pesticides BAYER CROPSCIENCE AG (DE) 2010-10-07 US disclosed
US-20100256195-A1 Tetrazole-substituted anthranilamides as pesticides BAYER CROPSCIENCE AG (DE) 2010-10-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100256195-A1 Tetrazole-substituted anthranilamides as pesticides ANTXR2, PNISR, H1-5 NTRK1 2506/4885KMT2A 1624/4885MEN1 2128/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.