SCHEMBL685553

SCHEMBL685553

[C-]#[N+]c1cc(C)c(NC(=O)c2cc(Cn3nnnc3C(F)(F)F)nn2-c2ccccc2Cl)c(C(=O)NC)c1

nearest known ligand 0.39

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
NTRK1 P04629 2/20 0.32
IDH1 O75874 1/20 0.32
CYP2C9 P11712 1/20 0.31
MEN1 O00255 1/20 0.30
KMT2A Q03164 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL685916 0.93 SMN1; SMN2 (0.31) NTRK1MEN1KMT2A
SCHEMBL685492 0.93 DHODH (0.32) NTRK1
SCHEMBL685899 0.90 DHODH (0.31) NTRK1
SCHEMBL13085565 0.88 ALDH1A1 (0.35) NTRK1IDH1MEN1KMT2A
SCHEMBL10076317 0.88 SLC2A1 (0.36) NTRK1IDH1MEN1KMT2A
SCHEMBL685551 0.87 IDH1 (0.32) IDH1MEN1KMT2A
SCHEMBL13085510 0.84 NTRK1 (0.34) NTRK1
SCHEMBL13085380 0.83 ALDH1A1 (0.36) NTRK1
SCHEMBL13085481 0.83 L3MBTL1 (0.38) NTRK1CYP2C9
SCHEMBL685534 0.83 DHODH (0.31)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170265470-A1 Anthranilamides in combination with fungicides BAYER INTELLECTUAL PROPERTY GMBH (DE) 2017-09-21 US disclosed
US-9700049-B2 Anthranilamides in combination with fungicides BAYER INTELLECTUAL PROPERTY GMBH (DE) 2017-07-11 US disclosed
US-20170156328-A1 USE OF AN ANTHRANILIC DIAMIDE DERIVATIVES WITH HETEROAROMATIC AND HETEROCYCLIC SUBSTITUENTS IN COMBINATION WITH A BIOLOGICALCONTROL AGENT BAYER INTELLECTUAL PROPERTY GMBH 2017-06-08 US disclosed
US-9572342-B2 Use of an anthranilic diamide derivatives with heteroaromatic and heterocyclic substituents in combination with a biologicalcontrol agent BAYER INTELLECTUAL PROPERTY GMBH (DE) 2017-02-21 US disclosed
US-9414595-B2 Use of anthranilic acid diamide derivatives for pest control in transgenic crops BAYER CROPSCIENCE AG (DE) 2016-08-16 US disclosed
US-20160128331-A1 ANTHRANILAMIDES IN COMBINATION WITH FUNGICIDES BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2016-05-12 US disclosed
US-9265255-B2 Anthranilamides in combination with fungicides BAYER INTELLECTUAL PROPERTY GMBH (DE) 2016-02-23 US disclosed
US-20160037775-A1 ACTIVE INGREDIENT COMBINATIONS HAVING INSECTICIDAL AND ACARICIDAL PROPERTIES BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2016-02-11 US disclosed
US-9198424-B2 Active ingredient combinations having insecticidal and acaricidal properties BAYER INTELLECTUAL PROPERTY GMBH (DE) 2015-12-01 US disclosed
US-20140329676-A1 USE OF ANTHRANILIC ACID DIAMIDE DERIVATIVES FOR PEST CONTROL IN TRANSGENIC CROPS BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2014-11-06 US disclosed
US-8658570-B2 Use of anthranilamide derivatives for controlling insects and spider mites by drenching, soil mixing, furrow treatment, drip application, soil, stem or flower injection, in hydroponic systems, by planting hole treatment or dip application, floating or seedbox application or by treating seed, and also for enhancing the stress tolerance of plants to abiotic stress BAYER CROPSCIENCE AG (DE) 2014-02-25 US disclosed
US-20120022112-A1 USE OF ANTHRANILAMIDE DERIVATIVES FOR CONTROLLING INSECTS AND SPIDER MITES BY DRENCHING, SOIL MIXING, FURROW TREATMENT, DRIP APPLICATION, SOIL, STEM OR FLOWER INJECTION, IN HYDROPONIC SYSTEMS, BY PLANTING HOLE TREATMENT OR DIP APPLICATION, FLOATING OR SEEDBOX APPLICATION OR BY TREATING SEED, AND ALSO FOR ENHANCING THE STRESS TOLERANCE OF PLANTS TO ABIOTIC STRESS BAYER CROPSCIENCE AG (DE) 2012-01-26 US disclosed
US-20120010073-A1 Anthranilamides in combination with fungicides BAYER CROPSCIENCE AG (DE) 2012-01-12 US disclosed
US-20110311503-A1 Active ingredient combinations having insecticidal and acaricidal properties BAYER CROPSCIENCE AG (DE) 2011-12-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120010073-A1 Anthranilamides in combination with fungicides AADAC, ANTXR2, CYP51A1 NTRK1 4774/4885IDH1 949/4885CYP2C9 113/4885
US-20120022112-A1 USE OF ANTHRANILAMIDE DERIVATIVES FOR CONTROLLING INSECTS AND SPIDER MITES BY DRENCHING, SOIL MIXING, FURROW TREATMENT, DRIP APPLICATION, SOIL, STEM OR FLOWER INJECTION, IN HYDROPONIC SYSTEMS, BY PLANTING HOLE TREATMENT OR DIP APPLICATION, FLOATING OR SEEDBOX APPLICATION OR BY TREATING SEED, AND ALSO FOR ENHANCING THE STRESS TOLERANCE OF PLANTS TO ABIOTIC STRESS CDY1; CDY1B, DHX9, DHX29 NTRK1 3877/4885IDH1 1415/4885CYP2C9 1512/4885
US-20140329676-A1 USE OF ANTHRANILIC ACID DIAMIDE DERIVATIVES FOR PEST CONTROL IN TRANSGENIC CROPS AADAC, DDT, QDPR NTRK1 4273/4885IDH1 80/4885CYP2C9 1477/4885
US-20160128331-A1 ANTHRANILAMIDES IN COMBINATION WITH FUNGICIDES AADAC, ANTXR2, CYP51A1 NTRK1 4774/4885IDH1 949/4885CYP2C9 113/4885
US-20170265470-A1 Anthranilamides in combination with fungicides AADAC, ANTXR2, CYP51A1 NTRK1 4774/4885IDH1 949/4885CYP2C9 113/4885
US-20170156328-A1 USE OF AN ANTHRANILIC DIAMIDE DERIVATIVES WITH HETEROAROMATIC AND HETEROCYCLIC SUBSTITUENTS IN COMBINATION WITH A BIOLOGICALCONTROL AGENT CYC1, TPD52L2, DBF4 NTRK1 4471/4885IDH1 45/4885CYP2C9 1971/4885
US-20110311503-A1 Active ingredient combinations having insecticidal and acaricidal properties ACHE, ACAT1, ACAT2 NTRK1 4722/4885IDH1 1837/4885CYP2C9 918/4885
US-20160037775-A1 ACTIVE INGREDIENT COMBINATIONS HAVING INSECTICIDAL AND ACARICIDAL PROPERTIES ACHE, ACAT1, ACAT2 NTRK1 4722/4885IDH1 1837/4885CYP2C9 918/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.