SCHEMBL684736

SCHEMBL684736

CNC(=O)c1cc(Cl)cc(C)c1NC(=O)c1cc(Cn2nnnc2C(F)(F)F)nn1-c1ncccc1Cl

nearest known ligand 0.63

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
NTRK1 P04629 3/20 0.33
DHODH Q02127 3/20 0.33
SLC2A1 P11166 2/20 0.32
SLC2A3 P11169 2/20 0.32
SLC2A4 P14672 2/20 0.32
SLC2A2 P11168 1/20 0.32
MALT1 Q9UDY8 3/20 0.31
PDE10A Q9Y233 1/20 0.31
NR3C1 P04150 1/20 0.31
LMNA P02545 1/20 0.31
POLB P06746 1/20 0.31
TRPV1 Q8NER1 1/20 0.30
STIM1 Q13586 1/20 0.30
ORAI1 Q96D31 1/20 0.30
ALDH1A1 P00352 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL687025 0.94 DHODH (0.32) NTRK1DHODHMALT1
SCHEMBL13085129 0.94 DHODH (0.33) NTRK1DHODHSLC2A1SLC2A3SLC2A4
SCHEMBL13085032 0.94 NTRK1 (0.34) NTRK1DHODHMALT1LMNAPOLB
SCHEMBL11928398 0.94 NTRK1 (0.34) NTRK1DHODHSLC2A1SLC2A3SLC2A4
SCHEMBL13085016 0.93 DHODH (0.35) NTRK1DHODHSLC2A1SLC2A3SLC2A4
SCHEMBL11928601 0.93 DHODH (0.34) NTRK1DHODHSLC2A1SLC2A3SLC2A4
SCHEMBL684739 0.93 DHODH (0.32) NTRK1DHODHSLC2A1SLC2A3SLC2A4
SCHEMBL13085417 0.93 NTRK1 (0.32) NTRK1PDE10ANR3C1
SCHEMBL684744 0.93 DHODH (0.32) NTRK1DHODHSLC2A1SLC2A3SLC2A4
SCHEMBL685550 0.93 SLC2A1 (0.36) NTRK1DHODHSLC2A1SLC2A3SLC2A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9968086-B2 Active ingredient combinations having insecticidal and acaricidal properties BAYER INTELLECTUAL PROPERTY GMBH (DE) 2018-05-15 US disclosed
US-9968086-B2 Active ingredient combinations having insecticidal and acaricidal properties BAYER INTELLECTUAL PROPERTY GMBH (DE) 2018-05-15 US disclosed
US-9854802-B2 Use of an anthranilic diamide derivatives with heteroaromatic and heterocyclic substituents in combination with a biological control agent BAYER INTELLECTUAL PROPERTY GMBH (DE) 2018-01-02 US disclosed
US-20170265470-A1 Anthranilamides in combination with fungicides BAYER INTELLECTUAL PROPERTY GMBH (DE) 2017-09-21 US disclosed
US-20170265470-A1 Anthranilamides in combination with fungicides BAYER INTELLECTUAL PROPERTY GMBH (DE) 2017-09-21 US disclosed
US-9700049-B2 Anthranilamides in combination with fungicides BAYER INTELLECTUAL PROPERTY GMBH (DE) 2017-07-11 US disclosed
US-9700049-B2 Anthranilamides in combination with fungicides BAYER INTELLECTUAL PROPERTY GMBH (DE) 2017-07-11 US disclosed
US-20170156328-A1 USE OF AN ANTHRANILIC DIAMIDE DERIVATIVES WITH HETEROAROMATIC AND HETEROCYCLIC SUBSTITUENTS IN COMBINATION WITH A BIOLOGICALCONTROL AGENT BAYER INTELLECTUAL PROPERTY GMBH 2017-06-08 US disclosed
US-20170156328-A1 USE OF AN ANTHRANILIC DIAMIDE DERIVATIVES WITH HETEROAROMATIC AND HETEROCYCLIC SUBSTITUENTS IN COMBINATION WITH A BIOLOGICALCONTROL AGENT BAYER INTELLECTUAL PROPERTY GMBH 2017-06-08 US disclosed
US-9572342-B2 Use of an anthranilic diamide derivatives with heteroaromatic and heterocyclic substituents in combination with a biologicalcontrol agent BAYER INTELLECTUAL PROPERTY GMBH (DE) 2017-02-21 US disclosed
US-20120022112-A1 USE OF ANTHRANILAMIDE DERIVATIVES FOR CONTROLLING INSECTS AND SPIDER MITES BY DRENCHING, SOIL MIXING, FURROW TREATMENT, DRIP APPLICATION, SOIL, STEM OR FLOWER INJECTION, IN HYDROPONIC SYSTEMS, BY PLANTING HOLE TREATMENT OR DIP APPLICATION, FLOATING OR SEEDBOX APPLICATION OR BY TREATING SEED, AND ALSO FOR ENHANCING THE STRESS TOLERANCE OF PLANTS TO ABIOTIC STRESS BAYER CROPSCIENCE AG (DE) 2012-01-26 US disclosed
WO-2012010525-A2 USE OF ANTHRANILIC ACID AMIDE DERIVATIVES FOR CONTROLLING INSECTS AND SPIDER MITES BY WATERING, MIXING WITH SOIL, DRENCH TREATMENT, DROPLET APPLICATION, INJECTION INTO THE SOIL, STEMS OR BLOSSOMS, IN HYDROPONIC SYSTEMS, BY TREATING THE PLANTING HOLE OR IMMERSION APPLICATION, FLOATING OR SEED BOX APPLICATION OR BY THE TREATMENT OF SEEDS, AND FOR INCREASING THE STRESS TOLERANCE IN PLANTS TO ABIOTIC STRESS BAYER CROPSCIENCE AG (DE) 2012-01-26 WO disclosed
US-20120010073-A1 Anthranilamides in combination with fungicides BAYER CROPSCIENCE AG (DE) 2012-01-12 US disclosed
US-20120010073-A1 Anthranilamides in combination with fungicides BAYER CROPSCIENCE AG (DE) 2012-01-12 US disclosed
WO-2011157778-A1 ACTIVE SUBSTANCE COMBINATIONS WITH INSECTICIDE AND ACARICIDE PROPERTIES BAYER CROPSCIENCE AG (DE) 2011-12-22 WO disclosed
US-20110311503-A1 Active ingredient combinations having insecticidal and acaricidal properties BAYER CROPSCIENCE AG (DE) 2011-12-22 US disclosed
US-20110311503-A1 Active ingredient combinations having insecticidal and acaricidal properties BAYER CROPSCIENCE AG (DE) 2011-12-22 US disclosed
US-20100256195-A1 Tetrazole-substituted anthranilamides as pesticides BAYER CROPSCIENCE AG (DE) 2010-10-07 US disclosed
US-20100256195-A1 Tetrazole-substituted anthranilamides as pesticides BAYER CROPSCIENCE AG (DE) 2010-10-07 US disclosed
WO-2010069502-A2 TETRAZOLE SUBSTITUTED ANTHRANILIC ACID AMIDES AS PESTICIDES BAYER CROPSCIENCE AG (DE) 2010-06-24 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100256195-A1 Tetrazole-substituted anthranilamides as pesticides ANTXR2, PNISR, H1-5 NTRK1 2506/4885DHODH 2604/4885SLC2A1 2324/4885
US-20120010073-A1 Anthranilamides in combination with fungicides AADAC, ANTXR2, CYP51A1 NTRK1 4774/4885DHODH 815/4885SLC2A1 4485/4885
US-20120022112-A1 USE OF ANTHRANILAMIDE DERIVATIVES FOR CONTROLLING INSECTS AND SPIDER MITES BY DRENCHING, SOIL MIXING, FURROW TREATMENT, DRIP APPLICATION, SOIL, STEM OR FLOWER INJECTION, IN HYDROPONIC SYSTEMS, BY PLANTING HOLE TREATMENT OR DIP APPLICATION, FLOATING OR SEEDBOX APPLICATION OR BY TREATING SEED, AND ALSO FOR ENHANCING THE STRESS TOLERANCE OF PLANTS TO ABIOTIC STRESS CDY1; CDY1B, DHX9, DHX29 NTRK1 3877/4885DHODH 265/4885SLC2A1 2970/4885
US-20170265470-A1 Anthranilamides in combination with fungicides AADAC, ANTXR2, CYP51A1 NTRK1 4774/4885DHODH 815/4885SLC2A1 4485/4885
US-20170156328-A1 USE OF AN ANTHRANILIC DIAMIDE DERIVATIVES WITH HETEROAROMATIC AND HETEROCYCLIC SUBSTITUENTS IN COMBINATION WITH A BIOLOGICALCONTROL AGENT CYC1, TPD52L2, DBF4 NTRK1 4471/4885DHODH 165/4885SLC2A1 4830/4885
US-20110311503-A1 Active ingredient combinations having insecticidal and acaricidal properties ACHE, ACAT1, ACAT2 NTRK1 4722/4885DHODH 1758/4885SLC2A1 4309/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.