Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dimethylformamide SCHEMBL314310 | 0.95 | LMNA (0.60) | LMNATSHRTHRB | |
| Dimethylformamide SCHEMBL133174 | 0.91 | LMNA (0.55) | LMNATSHRTHRB | |
| Dimethylformamide SCHEMBL9464389 | 0.83 | TSHR (0.47) | LMNATSHRTHRB | |
| Acetaldehyde SCHEMBL22361219 | 0.83 | LMNA (0.63) | LMNATSHRTHRB | |
| Ethylene SCHEMBL4935788 | 0.80 | LMNA (0.75) | LMNATHRB | |
| Ethylene SCHEMBL3362390 | 0.80 | LMNA (0.86) | LMNATHRB | |
| Ethylene SCHEMBL555416 | 0.80 | LMNA (0.86) | LMNATHRB | |
| Biphenyl SCHEMBL134670 | 0.79 | LMNA (0.41) | LMNATSHR | |
| Acrolein SCHEMBL3930769 | 0.79 | LMNA (0.57) | LMNATSHRTHRB | |
| Dimethylformamide SCHEMBL28172576 | 0.78 | LMNA (0.39) | LMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8716481-B2 | Process for the preparation of 6-substituted-1-(2H)-isoquinolinones | SANOFI (FR) | 2014-05-06 | — | — | US | disclosed |
| EP-1727803-B1 | PROCESSES FOR PREPARING SUBSTITUTED N-ARYL-N'-[3-(1H-PYRAZOL-5-YL)PHENYL] UREAS AND INTERMEDIATES THEREOF | ARENA PHARM INC (US) | 2012-03-07 | — | — | EP | disclosed |
| US-20110021779-A1 | PROCESS FOR THE PREPARATION OF 6-SUBSTITUTED-1-(2H)-ISOQUINOLINONES | SANOFI-AVENTIS (FR) | 2011-01-27 | — | — | US | disclosed |
| EP-2240441-A1 | PROCESS FOR THE PREPARATION OF 6-SUBSTITUTED-1-(2H)-ISOQUINOLINONES | Sanofi-Aventis (FR) | 2010-10-20 | — | — | EP | disclosed |
| US-7812176-B2 | reacting hydrazone containing compound with isocyanate compound, deprotecting, halogenating; cyclization; 5-HT2A serotonin receptor modulators | ARENA PHARMACEUTICALS, INC. (US) | 2010-10-12 | — | — | US | disclosed |
| WO-2009080335-A1 | PROCESS FOR THE PREPARATION OF 6-SUBSTITUTED-1-(2H)-ISOQUINOLINONES | SANOFI-AVENTIS (FR) | 2009-07-02 | — | — | WO | disclosed |
| US-7312342-B2 | Process for the preparation of (3-cyano-1h-indol-7-yl) (4-(4-fluorophenethyl) piperazin-1-yl)-methanone and salts thereof | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2007-12-25 | — | — | US | disclosed |
| US-20070293685-A1 | reacting hydrazone containing compound with isocyanate compound, deprotecting, halogenating; cyclization; 5-HT2A serotonin receptor modulators | ARENA PHARMACEUTICALS, INC. (US) | 2007-12-20 | — | — | US | disclosed |
| EP-1727803-A1 | PROCESSES FOR PREPARING SUBSTITUTED N-ARYL-N'-[3-(1H-PYRAZOL-5-YL)PHENYL] UREAS AND INTERMEDIATES THEREOF | Arena Pharmaceuticals, Inc. (US) | 2006-12-06 | — | — | EP | disclosed |
| WO-2005103011-A1 | PROCESSES FOR PREPARING SUBSTITUTED N-ARYL-N’-[3-(1H-PYRAZOL-5-YL) PHENYL] UREAS AND INTERMEDIATES THEREOF | ARENA PHARMACEUTICALS, INC. (US) | 2005-11-03 | — | — | WO | disclosed |
| EP-1353906-B1 | PROCESS FOR THE PREPARATION OF (3-CYANO-1H-INDOL-7-YL)(4-(4-FLUOROPHENETHYL)PIPERAZIN-1-YL)-METHANONE AND SALTS THEREOF | MERCK PATENT GMBH (DE) | 2004-06-23 | — | — | EP | disclosed |
| WO-2004028450-A2 | PROCESS OF MAKING PHENYLPYRAZOLES USEFUL AS SELECTIVE 5HT2A MODULATORS AND INTERMEDIATES THEREOF | ARENA PHARMACEUTICALS, INC. (US) | 2004-04-08 | — | — | WO | disclosed |
| US-20040063723-A1 | Process for the preparation of (3-cyano-1h-indol-7-yl) (4-(4-fluorophenethyl) piperazin-1-yl)- methanone and salts thereof | MERCK PATENT GMBH (DE) | 2004-04-01 | — | — | US | disclosed |
| EP-1353906-A1 | PROCESS FOR THE PREPARATION OF (3-CYANO-1H-INDOL-7-YL)(4-(4-FLUOROPHENETHYL)PIPERAZIN-1-YL)-METHANONE AND SALTS THEREOF | MERCK PATENT GmbH (DE) | 2003-10-22 | — | — | EP | disclosed |
| WO-2002059092-A1 | PROCESS FOR THE PREPARATION OF (3-CYANO-1H-INDOL-7-YL)(4-(4-FLUOROPHENETHYL)PIPERAZIN-1-YL)-METHANONE AND SALTS THEREOF | MERCK PATENT GMBH (DE) | 2002-08-01 | — | — | WO | disclosed |
| US-3976639-A | Intermediates for indoles | HOFFMANN-LA ROCHE INC. (US) | 1976-08-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110021779-A1 | PROCESS FOR THE PREPARATION OF 6-SUBSTITUTED-1-(2H)-ISOQUINOLINONES | CYP1B1, CYP1A1, NQO1 | LMNA 1159/4885TSHR 4350/4885THRB 4527/4885 |
| US-20040063723-A1 | Process for the preparation of (3-cyano-1h-indol-7-yl) (4-(4-fluorophenethyl) piperazin-1-yl)- methanone and salts thereof | TPH1, TPH2, IDO1 | LMNA 1134/4885TSHR 2436/4885THRB 2872/4885 |
| US-20070293685-A1 | reacting hydrazone containing compound with isocyanate compound, deprotecting, halogenating; cyclization; 5-HT2A serotonin receptor modulators | HTR5A, HTR2C, HTR2A | LMNA 3513/4885TSHR 91/4885THRB 889/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.