Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | CA5A | P35218 | 1/20 | 0.41 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.39 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30938682 | 0.82 | MAPT (0.62) | MAPTSMN1; SMN2ALDH1A1LMNATSHR | |
| SCHEMBL22558313 | 0.81 | MAPT (0.56) | MAPTSMN1; SMN2ALDH1A1LMNASLC9A1 | |
| SCHEMBL29009123 | 0.80 | HSD11B1 (0.44) | MAPTSMN1; SMN2ALDH1A1LMNAHSD11B1 | |
| SCHEMBL28229562 | 0.79 | PTGS2 (0.57) | MAPTSMN1; SMN2ALDH1A1LMNASLC9A1 | |
| SCHEMBL28393506 | 0.78 | PTGS2 (0.53) | MAPTSMN1; SMN2ALDH1A1LMNAMEN1 | |
| SCHEMBL28888736 | 0.77 | GRM5 (0.46) | MAPTSMN1; SMN2ALDH1A1LMNAHSD11B1 | |
| SCHEMBL28080757 | 0.77 | BRD4 (0.59) | MAPTSMN1; SMN2ALDH1A1LMNATSHR | |
| SCHEMBL30938679 | 0.75 | CA2 (0.57) | MAPTSMN1; SMN2ALDH1A1LMNASLC9A1 | |
| SCHEMBL26252983 | 0.75 | CA2 (0.57) | MAPTSMN1; SMN2ALDH1A1LMNASLC9A1 | |
| SCHEMBL28453359 | 0.73 | PTGS2 (0.51) | MAPTSMN1; SMN2ALDH1A1LMNASLC9A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130243727-A1 | TRIAZOLES AS INHIBITORS OF FATTY ACID SYNTHASE | INFINITY PHARMACEUTICALS, INC. (US) | 2013-09-19 | — | — | US | disclosed |
| US-20130243727-A1 | TRIAZOLES AS INHIBITORS OF FATTY ACID SYNTHASE | INFINITY PHARMACEUTICALS, INC. (US) | 2013-09-19 | — | — | US | disclosed |
| US-20130243727-A1 | TRIAZOLES AS INHIBITORS OF FATTY ACID SYNTHASE | INFINITY PHARMACEUTICALS, INC. (US) | 2013-09-19 | — | — | US | disclosed |
| US-8450350-B2 | Triazoles as inhibitors of fatty acid synthase | INFINITY PHARMACEUTICALS, INC. (US) | 2013-05-28 | — | — | US | disclosed |
| US-8450350-B2 | Triazoles as inhibitors of fatty acid synthase | INFINITY PHARMACEUTICALS, INC. (US) | 2013-05-28 | — | — | US | disclosed |
| US-8450350-B2 | Triazoles as inhibitors of fatty acid synthase | INFINITY PHARMACEUTICALS, INC. (US) | 2013-05-28 | — | — | US | disclosed |
| WO-2011140296-A1 | TRIAZOLES AS INHIBITORS OF FATTY ACID SYNTHASE | Infinity Pharmaceuticals (US) | 2011-11-10 | — | — | WO | disclosed |
| WO-2011140296-A1 | TRIAZOLES AS INHIBITORS OF FATTY ACID SYNTHASE | Infinity Pharmaceuticals (US) | 2011-11-10 | — | — | WO | disclosed |
| US-20110274654-A1 | TRIAZOLES AS INHIBITORS OF FATTY ACID SYNTHASE | INFINITY PHARMACEUTICALS INC. | 2011-11-10 | — | — | US | disclosed |
| US-20110274654-A1 | TRIAZOLES AS INHIBITORS OF FATTY ACID SYNTHASE | INFINITY PHARMACEUTICALS INC. | 2011-11-10 | — | — | US | disclosed |
| US-20110274654-A1 | TRIAZOLES AS INHIBITORS OF FATTY ACID SYNTHASE | INFINITY PHARMACEUTICALS INC. | 2011-11-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130243727-A1 | TRIAZOLES AS INHIBITORS OF FATTY ACID SYNTHASE | FASN, SCD, FADS1 | MAPT 3941/4885SMN1; SMN2 4830/4885ALDH1A1 408/4885 |
| US-20110274654-A1 | TRIAZOLES AS INHIBITORS OF FATTY ACID SYNTHASE | FASN, SCD, FADS1 | MAPT 3941/4885SMN1; SMN2 4830/4885ALDH1A1 408/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.