SCHEMBL1316420

SCHEMBL1316420

O=C(Nc1cc(-n2cccn2)ccc1C(=O)O)c1cncc(-c2ccccc2)c1

nearest known ligand 0.47

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.47
TBK1 Q9UHD2 4/20 0.46
IKBKE Q14164 2/20 0.46
ACLY P53396 2/20 0.44
KDM4D Q6B0I6 1/20 0.43
KDM4C Q9H3R0 1/20 0.43
DHODH Q02127 1/20 0.42
KAT6A Q92794 2/20 0.41
AAK1 Q2M2I8 1/20 0.41
TEK Q02763 1/20 0.41
HDAC1 Q13547 2/20 0.40
SUCNR1 Q9BXA5 1/20 0.40
CCNC P24863 1/20 0.40
CDK8 P49336 1/20 0.40
HDAC3 O15379 1/20 0.40
HDAC2 Q92769 1/20 0.40
SIRT2 Q8IXJ6 1/20 0.40
SIRT1 Q96EB6 1/20 0.40
SIRT3 Q9NTG7 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1316086 0.99 ALDH1A1 (0.46) ALDH1A1TBK1IKBKEACLYKDM4D
SCHEMBL1316084 0.91 TBK1 (0.44) ALDH1A1TBK1IKBKEKAT6AAAK1
SCHEMBL1316821 0.87 TBK1 (0.43) TBK1IKBKEKAT6AAAK1TEK
SCHEMBL2274841 0.81 ACLY (0.54) TBK1IKBKEACLYDHODHKAT6A
SCHEMBL1315751 0.81 ACLY (0.64) ALDH1A1ACLYKDM4DKDM4CDHODH
SCHEMBL12118163 0.80 HDAC1 (0.52) ALDH1A1ACLYDHODHHDAC1CCNC
SCHEMBL1315559 0.80 HDAC1 (0.51) ALDH1A1ACLYDHODHHDAC1CCNC
SCHEMBL12118152 0.79 ACLY (0.59) ALDH1A1ACLYKDM4DKDM4CDHODH
SCHEMBL1316456 0.79 ACLY (0.50) TBK1IKBKEACLYHDAC1HDAC2
SCHEMBL12118206 0.79 SCN9A (0.52) ALDH1A1ACLYHDAC1HDAC3HDAC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8492582-B2 N-acyl anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2013-07-23 US disclosed
US-8492582-B2 N-acyl anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2013-07-23 US disclosed
US-8492582-B2 N-acyl anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2013-07-23 US disclosed
US-20110275797-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2011-11-10 US disclosed
US-20110275797-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2011-11-10 US disclosed
US-20110275797-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2011-11-10 US disclosed
EP-2385036-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF Toyama Chemical Co., Ltd. (JP) 2011-11-09 EP disclosed
WO-2010087430-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF 富山化学工業株式会社 (JP) 2010-08-05 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110275797-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF COL14A1, COL2A1, COL1A1 ALDH1A1 813/4885TBK1 4001/4885IKBKE 1828/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.