SCHEMBL2274841

SCHEMBL2274841

O=C(Nc1cc(-c2ccccc2)ccc1C(=O)O)c1cccc(-n2cccn2)c1

nearest known ligand 0.54

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ACLY P53396 4/20 0.54
KAT6A Q92794 2/20 0.53
SUCNR1 Q9BXA5 1/20 0.52
SERPINE1 P05121 1/20 0.47
MEN1 O00255 1/20 0.47
PKM P14618 1/20 0.47
KMT2A Q03164 1/20 0.47
DHODH Q02127 1/20 0.46
HDAC1 Q13547 6/20 0.45
HDAC2 Q92769 3/20 0.45
TEK Q02763 1/20 0.45
TBK1 Q9UHD2 2/20 0.45
HDAC3 O15379 2/20 0.44
FFAR4 Q5NUL3 1/20 0.44
IKBKE Q14164 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1316456 0.85 ACLY (0.50) ACLYHDAC1HDAC2TBK1IKBKE
SCHEMBL27716636 0.85 KAT6A (0.45) ACLYKAT6ASUCNR1HDAC1HDAC2
SCHEMBL2273063 0.85 KAT6A (0.50) KAT6ASERPINE1MEN1PKMKMT2A
SCHEMBL1316515 0.84 ACLY (0.49) ACLYKAT6AHDAC1HDAC2TBK1
SCHEMBL2269037 0.83 ACLY (0.59) ACLYSUCNR1SERPINE1MEN1PKM
SCHEMBL2271258 0.83 ACLY (0.67) ACLYSUCNR1MEN1KMT2A
SCHEMBL4215412 0.83 ACLY (0.52) ACLYKAT6ATBK1FFAR4IKBKE
SCHEMBL1316420 0.81 ALDH1A1 (0.47) ACLYKAT6ASUCNR1DHODHHDAC1
SCHEMBL2275720 0.81 SUCNR1 (0.73) ACLYSUCNR1SERPINE1MEN1PKM
SCHEMBL1316086 0.81 ALDH1A1 (0.46) ACLYKAT6ASUCNR1DHODHHDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101094829-B novel anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO.,LTD. (JP) 2012-02-08 CN disclosed
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
CN-101094829-A Novel anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO LTD (JP) 2007-12-26 CN disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 ACLY 653/4885KAT6A 491/4885SUCNR1 637/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.