Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 6/20 | 0.76 |
| ▸ | ACHE | P22303 | 6/20 | 0.76 |
| ▸ | EP300 | Q09472 | 6/20 | 0.76 |
| ▸ | MAPT | P10636 | 5/20 | 0.76 |
| ▸ | RAD52 | P43351 | 5/20 | 0.76 |
| ▸ | KDM1A | O60341 | 4/20 | 0.76 |
| ▸ | LMNA | P02545 | 4/20 | 0.76 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.76 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.76 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.76 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.76 |
| ▸ | RAC1 | P63000 | 2/20 | 0.74 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.73 |
| ▸ | MAOB | P27338 | 1/20 | 0.73 |
| ▸ | POLB | P06746 | 1/20 | 0.73 |
| ▸ | GAA | P10253 | 1/20 | 0.73 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.70 |
| ▸ | BCHE | P06276 | 2/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29331825 | 0.89 | ACHE (0.59) | CYP3A4ACHEEP300MAPTRAD52 | |
| SCHEMBL25892349 | 0.87 | CYP3A4 (0.79) | CYP3A4ACHEEP300MAPTRAD52 | |
| SCHEMBL14477482 | 0.87 | CYP3A4 (0.76) | CYP3A4ACHEEP300MAPTRAD52 | |
| Palmitine SCHEMBL29350054 | 0.86 | CYP3A4 (1.00) | CYP3A4ACHEEP300MAPTRAD52 | |
| Palmitine SCHEMBL29471136 | 0.86 | CYP3A4 (1.00) | CYP3A4ACHEEP300MAPTRAD52 | |
| Palmitine SCHEMBL562120 | 0.86 | CYP3A4 (1.00) | CYP3A4ACHEEP300MAPTRAD52 | |
| SCHEMBL2742479 | 0.85 | RAC1 (1.00) | CYP3A4ACHEEP300MAPTRAD52 | |
| Palmitine SCHEMBL754702 | 0.85 | CYP3A4 (1.00) | CYP3A4ACHEEP300MAPTRAD52 | |
| Palmitine SCHEMBL2445279 | 0.85 | CYP3A4 (0.98) | CYP3A4ACHEEP300MAPTRAD52 | |
| Palmitine SCHEMBL29376263 | 0.85 | CYP3A4 (1.00) | CYP3A4ACHEEP300MAPTRAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230348457-A1 | BERBERINE SALTS, URSODEOXYCHOLIC SALTS AND COMBINATIONS, METHODS OF PREPARATION AND APPLICATION THEREOF | SHENZHEN HIGHTIDE BIOPHARMACEUTICAL LTD (CN) | 2023-11-02 | — | — | US | disclosed |
| US-20230295151-A1 | BERBERINE SALTS, URSODEOXYCHOLIC SALTS AND COMBINATIONS, METHODS OF PREPARATION AND APPLICATION THEREOF | SHENZHEN HIGHTIDE BIOPHARMACEUTICAL, LTD. (CN) | 2023-09-21 | — | — | US | disclosed |
| US-11685735-B2 | Pharmaceutical composition comprising berberine salts for the treatment of various diseases or disorders | SHENZHEN HIGHTIDE BIOPHARMACEUTICAL, LTD. (CN) | 2023-06-27 | — | — | US | disclosed |
| US-20180050048-A1 | CONJUGATE COMPOUNDS OF URSODEOXYCHOLIC, BERBERINE OR L-CARNITINE, AND COMPOSITIONS AND METHODS THEREOF | SHENZHEN HIGHTIDE BIOPHARMACEUTICAL, LTD. (CN) | 2018-02-22 | — | — | US | disclosed |
| US-20170037043-A1 | BERBERINE SALTS, URSODEOXYCHOLIC SALTS AND COMBINATIONS, METHODS OF PREPARATION AND APPLICATION THEREOF | SHENZHEN HIGHTIDE BIOPHARMACEUTICAL, LTD. (CN) | 2017-02-09 | — | — | US | disclosed |
| US-9233903-B2 | Pharmaceutical substances on the basis of mitochondria-addressed antioxidants | MITOTECH SA (LU) | 2016-01-12 | — | — | US | disclosed |
| US-20120259110-A1 | PHARMACEUTICAL SUBSTANCES ON THE BASIS OF MITOCHONDRIA-ADDRESSED ANTIOXIDANTS | MITOTECH SA (LU) | 2012-10-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170037043-A1 | BERBERINE SALTS, URSODEOXYCHOLIC SALTS AND COMBINATIONS, METHODS OF PREPARATION AND APPLICATION THEREOF | CYP27A1, NR1H4, CYP7A1 | CYP3A4 213/4885ACHE 348/4885EP300 4008/4885 |
| US-20230348457-A1 | BERBERINE SALTS, URSODEOXYCHOLIC SALTS AND COMBINATIONS, METHODS OF PREPARATION AND APPLICATION THEREOF | CYP27A1, NR1H4, CYP7A1 | CYP3A4 213/4885ACHE 348/4885EP300 4008/4885 |
| US-20120259110-A1 | PHARMACEUTICAL SUBSTANCES ON THE BASIS OF MITOCHONDRIA-ADDRESSED ANTIOXIDANTS | SQOR, MT-ND2, PRDX5 | CYP3A4 528/4885ACHE 911/4885EP300 4412/4885 |
| US-20180050048-A1 | CONJUGATE COMPOUNDS OF URSODEOXYCHOLIC, BERBERINE OR L-CARNITINE, AND COMPOSITIONS AND METHODS THEREOF | HMGCR, COASY, CPT1A | CYP3A4 2342/4885ACHE 2164/4885EP300 938/4885 |
| US-11685735-B2 | Pharmaceutical composition comprising berberine salts for the treatment of various diseases or disorders | CPT1B, CYP27A1, GLS2 | CYP3A4 212/4885ACHE 418/4885EP300 3995/4885 |
| US-20230295151-A1 | BERBERINE SALTS, URSODEOXYCHOLIC SALTS AND COMBINATIONS, METHODS OF PREPARATION AND APPLICATION THEREOF | CYP27A1, NR1H4, CYP7A1 | CYP3A4 213/4885ACHE 348/4885EP300 4008/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.