Sugi Predict

Sugi Predict / Compounds / SCHEMBL132927

SCHEMBL132927

SCHEMBL132927

Nc1nc2nc[nH]c2c(=O)n1[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1O

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PNP P00491 1/20 0.51
▸ HSPA5 P11021 2/20 0.50
▸ HSPA8 P11142 2/20 0.50
▸ LMNA P02545 3/20 0.47
▸ ALDH1A1 P00352 2/20 0.47
▸ MTOR P42345 2/20 0.47
▸ TP53 P04637 2/20 0.47
▸ GMNN O75496 1/20 0.47
▸ NFKB1 P19838 1/20 0.47
▸ DNMT1 P26358 1/20 0.47
▸ THPO P40225 1/20 0.47
▸ HTT P42858 1/20 0.47
▸ RAB9A P51151 1/20 0.47
▸ BLM P54132 1/20 0.47
▸ HBB P68871 1/20 0.47
▸ PMP22 Q01453 1/20 0.47
▸ MEN1 O00255 1/20 0.46
▸ KMT2A Q03164 1/20 0.46
▸ SMN1; SMN2 Q16637 2/20 0.45
▸ THRB P10828 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10496369 1.00 PNP (0.51) PNPHSPA5HSPA8LMNAALDH1A1
SCHEMBL10814765 1.00 PNP (0.51) PNPHSPA5HSPA8LMNAALDH1A1
SCHEMBL10814753 0.82 PNP (0.54) PNPHSPA5HSPA8LMNAALDH1A1
SCHEMBL132926 0.82 PNP (0.54) PNPHSPA5HSPA8LMNAALDH1A1
SCHEMBL375987 0.82 PNP (0.54) PNPHSPA5HSPA8LMNAALDH1A1
SCHEMBL10814776 0.82 PNP (0.54) PNPHSPA5HSPA8LMNAALDH1A1
SCHEMBL7948397 0.82 PNP (0.54) PNPHSPA5HSPA8LMNAALDH1A1
SCHEMBL10496354 0.82 PNP (0.54) PNPHSPA5HSPA8LMNAALDH1A1
SCHEMBL132928 0.82 PNP (0.54) PNPHSPA5HSPA8LMNAALDH1A1
SCHEMBL2185987 0.82 PNP (0.54) PNPHSPA5HSPA8LMNAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1414854-B Phosphonate compounds THE REGENTS OF THE UNIVERSITY OF CALIFORNIA SAN DIEGO (US) 2015-08-19 — — CN claimed
EP-1914237-B1 Phosphonate ester antiviral compounds UNIV CALIFORNIA (US) 2014-06-18 — — EP claimed
EP-1233770-B1 PHOSPHONATE COMPOUNDS UNIV CALIFORNIA AT SAN DIEGO (US) 2008-02-13 — — EP claimed
US-20060281706-A1 New phosphonate ester derivatives of drugs such as antivirals cidofovir, adefovir, tenofovir, azidothymidine (AZT), or bisphosphonates such as alendronate, or anticancers such as cytosine arabinoside; side effect reduction, less toxic; antiviral THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2006-12-14 — — US claimed
US-7098197-B2 An antiviral nucleoside in which the 5'-hydroxyl group has been substituted for a phosphonate or methyl phosphonate that is covalently linked to an alkylethanediol; osteoporosis; anticarcinogenic agents; viricides THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2006-08-29 — — US claimed
WO-2005090370-A1 PHARMACOLOGICALLY ACTIVE AGENTS CONTAINING ESTERIFIED PHOSPHONATES AND METHODS FOR USE THEREOF THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2005-09-29 — — WO claimed
US-20050192246-A1 Pharmacologically active agents containing esterified phosphonates and methods for use thereof US ARMY, SECRETARY OF THE ARMY 2005-09-01 — — US claimed
US-20050182019-A1 An antiviral nucleoside in which the 5'-hydroxyl group has been substituted for a phosphonate or methyl phosphonate that is covalently linked to an alkylethanediol; osteoporosis; anticarcinogenic agents; viricides THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2005-08-18 — — US claimed
US-20040127735-A1 New phosphonate ester derivatives of drugs such as antivirals cidofovir, adefovir, tenofovir, azidothymidine (AZT), or bisphosphonates such as alendronate, or anticancers such as cytosine arabinoside; side effect reduction, less toxic; antiviral THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2004-07-01 — — US claimed
US-20040019232-A1 Analogs of phosphonate and bisphosphonate compounds based on bone resorption suppressors (alendronic acid), viricides (cidofovir) and antineoplastic agents (bemcitabine); nontoxic; bioavailability; side effects reduction NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2004-01-29 — — US claimed
EP-1233770-A4 PHOSPHONATE COMPOUNDS UNIV CALIFORNIA AT SAN DIEGO (US) 2003-04-16 — — EP claimed
EP-1233770-A2 PHOSPHONATE COMPOUNDS The Regents of The University of California at San Diego (US) 2002-08-28 — — EP claimed
WO-2001039724-A2 PHOSPHONATE COMPOUNDS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN DIEGO (US) 2001-06-07 — — WO claimed
US-10071110-B2 Phosphonate compounds THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2018-09-11 — — US disclosed
CN-1414854-B Phosphonate compounds THE REGENTS OF THE UNIVERSITY OF CALIFORNIA SAN DIEGO (US) 2015-08-19 — — CN disclosed
US-20150141375-A1 Methods of Treating Viral Associated Diseases CHIMERIX, INC. 2015-05-21 — — US disclosed
US-6582947-B1 Nucleotide sequences coding enzymatic polypeptide for use in the virus treatment of cancer and viral infection BIO VICI (CH) 2003-06-24 — — US disclosed
EP-1233770-A4 PHOSPHONATE COMPOUNDS UNIV CALIFORNIA AT SAN DIEGO (US) 2003-04-16 — — EP disclosed
EP-1233770-A2 PHOSPHONATE COMPOUNDS The Regents of The University of California at San Diego (US) 2002-08-28 — — EP disclosed
WO-2001039724-A2 PHOSPHONATE COMPOUNDS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN DIEGO (US) 2001-06-07 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10071110-B2 Phosphonate compounds PHPT1, PHOSPHO1, PIK3CA PNP 74/4885HSPA5 4527/4885HSPA8 4433/4885
US-20060281706-A1 New phosphonate ester derivatives of drugs such as antivirals cidofovir, adefovir, tenofovir, azidothymidine (AZT), or bisphosphonates such as alendronate, or anticancers such as cytosine arabinoside; side effect reduction, less toxic; antiviral TYMP, ADA, DCTD PNP 19/4885HSPA5 4188/4885HSPA8 4579/4885
US-20040127735-A1 New phosphonate ester derivatives of drugs such as antivirals cidofovir, adefovir, tenofovir, azidothymidine (AZT), or bisphosphonates such as alendronate, or anticancers such as cytosine arabinoside; side effect reduction, less toxic; antiviral TYMP, ADA, DCTD PNP 19/4885HSPA5 4188/4885HSPA8 4579/4885
US-20040019232-A1 Analogs of phosphonate and bisphosphonate compounds based on bone resorption suppressors (alendronic acid), viricides (cidofovir) and antineoplastic agents (bemcitabine); nontoxic; bioavailability; side effects reduction BPGM, PPA1, INPP5D PNP 96/4885HSPA5 3800/4885HSPA8 4395/4885
US-20050192246-A1 Pharmacologically active agents containing esterified phosphonates and methods for use thereof PHPT1, PPIP5K2, PHOSPHO1 PNP 30/4885HSPA5 4130/4885HSPA8 4178/4885
US-20050182019-A1 An antiviral nucleoside in which the 5'-hydroxyl group has been substituted for a phosphonate or methyl phosphonate that is covalently linked to an alkylethanediol; osteoporosis; anticarcinogenic agents; viricides MTAP, SAMHD1, NT5C3B PNP 9/4885HSPA5 4510/4885HSPA8 3975/4885
US-20150141375-A1 Methods of Treating Viral Associated Diseases HAVCR2, EIF2AK2, TSLP PNP 727/4885HSPA5 349/4885HSPA8 2603/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.