Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 1/20 | 0.56 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.56 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.56 |
| ▸ | CCR3 | P51677 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | MC4R | P32245 | 1/20 | 0.53 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.53 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13958988 | 0.79 | SIGMAR1 (0.79) | ADRA1DADRA1AADRA1BCCR3MBTD1 | |
| SCHEMBL3240628 | 0.77 | CCR3 (0.63) | ADRA1DADRA1AADRA1BCCR3MC4R | |
| SCHEMBL13293708 | 0.77 | HRH3 (0.64) | KMT2AMBTD1L3MBTL3L3MBTL1POLB | |
| SCHEMBL22422491 | 0.77 | ADRA1D (0.58) | ADRA1DADRA1AADRA1BCCR3MC4R | |
| SCHEMBL6056974 | 0.76 | SLC6A3 (0.83) | CCR3KMT2ASIGMAR1SLC6A3HTR1A | |
| SCHEMBL7264546 | 0.76 | SLC6A3 (0.83) | CCR3KMT2ASIGMAR1SLC6A3HTR1A | |
| SCHEMBL14407778 | 0.76 | SLC6A3 (0.83) | CCR3KMT2ASIGMAR1SLC6A3HTR1A | |
| SCHEMBL13150782 | 0.76 | SLC6A3 (0.83) | CCR3KMT2ASIGMAR1SLC6A3HTR1A | |
| SCHEMBL10900749 | 0.75 | ALDH1A1 (0.57) | ADRA1DADRA1AADRA1BCCR3KMT2A | |
| SCHEMBL17830792 | 0.75 | SMN1; SMN2 (0.71) | KMT2AMC4RSIGMAR1LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008147864-A2 | METHODS OF USING PIPERAZINE COMPOUNDS IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-12-04 | — | — | WO | claimed |
| WO-2008147864-A2 | METHODS OF USING PIPERAZINE COMPOUNDS IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-12-04 | — | — | WO | disclosed |