Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 1/20 | 0.54 |
| ▸ | PLG | P00747 | 1/20 | 0.47 |
| ▸ | PLAU | P00749 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 3/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5591112 | 0.90 | KRAS (0.52) | KRASPLGPLAUCYP1A2SLC6A2 | |
| SCHEMBL13139566 | 0.89 | HTR7 (0.53) | KRASPLGPLAUCYP1A2AR | |
| SCHEMBL3184801 | 0.87 | KRAS (0.55) | KRASPLGPLAUCYP1A2SLC6A2 | |
| SCHEMBL14876295 | 0.85 | ATM (0.55) | KRASPLGPLAUSLC6A2AR | |
| SCHEMBL7354759 | 0.83 | RAB9A (0.52) | KRASPPARG | |
| SCHEMBL12475322 | 0.82 | PLG (0.51) | KRASPLGPLAUCYP1A2SLC6A2 | |
| SCHEMBL2420811 | 0.82 | CYP1A2 (0.53) | KRASPLGPLAUCYP1A2SLC6A2 | |
| SCHEMBL30764997 | 0.81 | PLG (0.48) | KRASPLGPLAUCYP1A2SLC6A2 | |
| SCHEMBL31735444 | 0.80 | MEN1 (0.46) | KRASPLGPLAUSLC6A2AR | |
| SCHEMBL3355607 | 0.79 | HTR7 (0.49) | KRASPLGPLAUCYP1A2SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100137363-A1 | Substituted Indoles And Methods Of Their Use | WYETH LLC (US) | 2010-06-03 | — | — | US | disclosed |
| US-7683091-B2 | Substituted indoles and methods of their use | WYETH (US) | 2010-03-23 | — | — | US | disclosed |
| US-20070043101-A1 | Substituted indoles and methods of their use | WYETH (US) | 2007-02-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070043101-A1 | Substituted indoles and methods of their use | INMT, AANAT, IDO2 | KRAS 464/4885PLG 4403/4885PLAU 4372/4885 |
| US-20100137363-A1 | Substituted Indoles And Methods Of Their Use | INMT, AANAT, IDO2 | KRAS 464/4885PLG 4403/4885PLAU 4372/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.