SCHEMBL13302005

SCHEMBL13302005

Cc1cc2cc(C(F)(F)F)cc3c(=C(C#N)C#N)c(=O)c(c1)c23

nearest known ligand 0.43

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ MCL1 Q07820 4/20 0.43
▸ RPS6KA3 P51812 1/20 0.30
▸ JAK3 P52333 1/20 0.30
▸ KIF11 P52732 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12113984 0.89 MCL1 (0.53) MCL1
SCHEMBL13302002 0.80 MCL1 (0.67) MCL1RPS6KA3JAK3
SCHEMBL14922764 0.77 MCL1 (0.70) MCL1
SCHEMBL27103870 0.68 CSNK2A2 (0.33) KIF11
SCHEMBL13301951 0.64 RAPGEF4 (0.35) —
SCHEMBL16601998 0.63 MCL1 (0.47) MCL1KIF11
SCHEMBL2367407 0.61 MCL1 (1.00) MCL1
SCHEMBL13694210 0.60 MCL1 (0.65) MCL1
SCHEMBL12114036 0.60 MCL1 (0.58) MCL1
SCHEMBL16269886 0.60 KIF11 (0.42) KIF11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7745083-B2 Electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2010-06-29 — — US disclosed
US-20090297218-A1 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE, AND ELECTROPHOTOGRAPHIC APPARATUS CANON KABUSHIKI KAISHA (JP) 2009-12-03 — — US disclosed
US-7592113-B2 Electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2009-09-22 — — US disclosed
US-20080233499-A1 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE, AND ELECTROPHOTOGRAPHIC APPARATUS CANON KABUSHIKI KAISHA (JP) 2008-09-25 — — US disclosed
US-7396622-B2 Having a charge generation layer containing a phenanthrene compound, a phenanthroline compound or an acenaphthene compound that has two oxo-, phenylimino- or dicyanovinylene groups that may be the same or different; charge-generating material is preferably hydroxygallium phthalocyanine. CANON KABUSHIKI KAISHA (JP) 2008-07-08 — — US disclosed
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