Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | PLA2G4B | P0C869 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | RXRA | P19793 | 1/20 | 0.46 |
| ▸ | RXRB | P28702 | 1/20 | 0.46 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.46 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.46 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | RARB | P10826 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1503527 | 0.88 | PKM (0.53) | PKMPLA2G4BMAPK1TSHRTP53 | |
| SCHEMBL13337491 | 0.84 | MAPT (0.58) | TSHRNPC1POLBRAB9ASMN1; SMN2 | |
| SCHEMBL31017671 | 0.78 | PKM (0.53) | PKMPLA2G4BMAPK1TSHRTP53 | |
| SCHEMBL13337424 | 0.77 | RXRA (0.50) | PKMPLA2G4BMAPK1TSHRTP53 | |
| SCHEMBL13337470 | 0.76 | RXRA (0.49) | PKMPLA2G4BMAPK1TSHRTP53 | |
| SCHEMBL23425517 | 0.76 | ADAM17 (0.50) | MMP1MMP9MMP13ADAM17 | |
| SCHEMBL8011558 | 0.75 | PKM (0.58) | PKMPLA2G4BMAPK1TSHRTP53 | |
| SCHEMBL13337501 | 0.75 | PKM (0.50) | PKMPLA2G4BMAPK1TSHRTP53 | |
| SCHEMBL17039268 | 0.75 | L3MBTL1 (0.59) | POLBRAB9AMMP1MMP9MMP13 | |
| SCHEMBL4398919 | 0.74 | PKM (0.56) | PKMPLA2G4BMAPK1TSHRTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8372885-B2 | Organic compounds and their uses | NOVARTIS AG (CH) | 2013-02-12 | — | — | US | disclosed |
| US-20100120872-A1 | ORGANIC COMPOUNDS AND THEIR USES | NOVARTIS AG (CH) | 2010-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100120872-A1 | ORGANIC COMPOUNDS AND THEIR USES | OAT, OTC, AOX1 | PKM 987/4885PLA2G4B 4249/4885MAPK1 4830/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.