Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 7/20 | 0.44 |
| ▸ | LTA4H | P09960 | 9/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1332745 | 0.93 | ALDH1A1 (0.47) | TMEM97SIGMAR1LTA4H | |
| SCHEMBL2157360 | 0.92 | SLC6A4 (0.48) | HTR1ADRD2HTR2AHRH1DRD3 | |
| Hydrochloric Acid SCHEMBL2157274 | 0.91 | SLC6A4 (0.48) | HTR1ADRD2HTR2AHRH1DRD3 | |
| Hydrochloric Acid SCHEMBL2157331 | 0.82 | KCNA5 (0.48) | HTR1ADRD2HTR2AHRH1DRD3 | |
| Hydrochloric Acid SCHEMBL2158456 | 0.81 | KCNA5 (0.45) | HTR1ADRD2HTR2ADRD3TMEM97 | |
| SCHEMBL2157136 | 0.79 | SLC6A3 (0.47) | SLC6A4SLC6A3 | |
| SCHEMBL1730306 | 0.71 | LTA4H (0.77) | HTR1ADRD2HTR2AHRH1DRD3 | |
| SCHEMBL7031231 | 0.71 | SIGMAR1 (0.68) | HTR1ADRD2HTR2AHRH1DRD3 | |
| SCHEMBL1299631 | 0.70 | SIGMAR1 (0.52) | SIGMAR1SLC6A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL2157442 | 0.70 | ALDH1A1 (0.69) | HTR1ADRD2HTR2AHRH1DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110281890-A1 | Piperidine and piperazine derivatives | M'S SCIENCE CORPORATION | 2011-11-17 | — | — | US | claimed |
| EP-1978959-B1 | PIPERIDINE AND PIPERAZINE DERIVATIVES | MS SCIENCE CORP (JP) | 2011-11-09 | — | — | EP | claimed |
| US-8183374-B2 | Piperidine and piperazine derivatives | M'S SCIENCE CORPORATION (JP) | 2012-05-22 | — | — | US | disclosed |
| EP-2340835-A1 | Piperidine and piperazine derivatives | M's Science Corporation (JP) | 2011-07-06 | — | — | EP | disclosed |
| US-20100256162-A1 | Piperazine and Piperidine Derivatives | AGY THERAPEUTICS, INC. (US) | 2010-10-07 | — | — | US | disclosed |
| US-20100137334-A1 | Piperidine and Piperazine Derivatives | SUN CONNIE L | 2010-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137334-A1 | Piperidine and Piperazine Derivatives | SIGMAR1, OPRM1, OPRD1 | HTR1A 23/4885DRD2 28/4885HTR2A 42/4885 |
| US-20110281890-A1 | Piperidine and piperazine derivatives | SIGMAR1, OPRM1, OPRD1 | HTR1A 49/4885DRD2 17/4885HTR2A 57/4885 |
| US-20100256162-A1 | Piperazine and Piperidine Derivatives | SIGMAR1, OPRM1, OPRD1 | HTR1A 50/4885DRD2 22/4885HTR2A 52/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.