SCHEMBL13401854

SCHEMBL13401854

O=c1c(Cc2ccc(F)cc2)nc2c(Cc3ccccc3)[nH]c(-c3ccc(O)cc3)cn1-2

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ABCB1 P08183 1/20 0.39
▸ ADORA3 P0DMS8 2/20 0.37
▸ PTGDR2 Q9Y5Y4 1/20 0.35
▸ ALDH1A1 P00352 3/20 0.35
▸ MEN1 O00255 2/20 0.35
▸ KMT2A Q03164 2/20 0.35
▸ CYP1A2 P05177 1/20 0.35
▸ CASP1 P29466 1/20 0.35
▸ CASP7 P55210 1/20 0.35
▸ HSD17B10 Q99714 1/20 0.35
▸ ARF6 P62330 1/20 0.35
▸ CDC7 O00311 2/20 0.34
▸ ADORA1 P30542 1/20 0.34
▸ XDH P47989 1/20 0.33
▸ TP53 P04637 1/20 0.33
▸ SMN1; SMN2 Q16637 1/20 0.33
▸ LTB4R Q15722 1/20 0.33
▸ MTOR P42345 1/20 0.33
▸ PARP1 P09874 1/20 0.33
▸ HTT P42858 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12293879 0.95 ABCB1 (0.42) ABCB1ADORA3ALDH1A1HSD17B10CDC7
SCHEMBL64690 0.95 ABCB1 (0.42) ABCB1ADORA3ALDH1A1HSD17B10CDC7
SCHEMBL954434 0.94 ABCB1 (0.41) ABCB1ADORA3ALDH1A1HSD17B10CDC7
SCHEMBL16154083 0.93 ADORA3 (0.38) ADORA3PTGDR2ALDH1A1MEN1KMT2A
SCHEMBL2680751 0.93 ABCB1 (0.40) ABCB1ADORA3ALDH1A1HSD17B10CDC7
SCHEMBL24329824 0.90 ADORA3 (0.39) ADORA3ALDH1A1MEN1KMT2ACYP1A2
SCHEMBL20841761 0.90 ABCB1 (0.39) ABCB1ADORA3ALDH1A1MEN1KMT2A
SCHEMBL20841749 0.90 ABCB1 (0.39) ABCB1ADORA3PTGDR2ALDH1A1CDC7
SCHEMBL10196941 0.90 ABCB1 (0.39) ABCB1ADORA3ALDH1A1CDC7ADORA1
SCHEMBL10196888 0.90 ABCB1 (0.39) ABCB1ADORA3ALDH1A1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12130292-B2 Full length kinase activity-conformation reporter KINCON BIOLABS GMBH (AT) 2024-10-29 — — US disclosed
US-20240239803-A1 SYNTHESIS OF COELENTERAZINE INTERNATIONAL PAPER COMPANY 2024-07-18 — — US disclosed
US-20240239803-A1 SYNTHESIS OF COELENTERAZINE INTERNATIONAL PAPER COMPANY 2024-07-18 — — US disclosed
US-20230366023-A1 METHODS AND COMPOSITIONS FOR BIOLUMINESCENCE-BASED SEQUENCING BGI SHENZHEN GROUP HOLDINGS CO. LIMITED (CN) 2023-11-16 — — US disclosed
US-20230366023-A1 METHODS AND COMPOSITIONS FOR BIOLUMINESCENCE-BASED SEQUENCING BGI SHENZHEN GROUP HOLDINGS CO. LIMITED (CN) 2023-11-16 — — US disclosed
EP-3519830-B1 FULL LENGTH KINASE ACTIVITY-CONFORMATION REPORTER KINCON BIOLABS GMBH (AT) 2023-07-19 — — EP disclosed
US-11691976-B2 Coelenterazine analogues PROMEGA CORPORATION (US) 2023-07-04 — — US disclosed
US-11691976-B2 Coelenterazine analogues PROMEGA CORPORATION (US) 2023-07-04 — — US disclosed
WO-2022170177-A1 FUSION PROTEINS AND METHODS OF USING THE SAME FOR THE DETECTION OF NEUTRALIZING ANTIBODIES THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 2022-08-11 — — WO disclosed
US-20220137060-A1 FULL LENGTH KINASE ACTIVITY-CONFORMATION REPORTER KINCON BIOLABS GMBH (AT) 2022-05-05 — — US disclosed
EP-3519830-A1 FULL LENGTH KINASE ACTIVITY-CONFORMATION REPORTER Universität Innsbruck (AT) 2019-08-07 — — EP disclosed
US-20190203187-A1 CHEMILUMINESCENT WETNESS INDICATOR FOR ABSORBENT PRODUCTS INTERNATIONAL PAPER COMPANY (US) 2019-07-04 — — US disclosed
WO-2018060415-A1 FULL LENGTH KINASE ACTIVITY-CONFORMATION REPORTER UNIVERSITÄT INNSBRUCK (AT) 2018-04-05 — — WO disclosed
WO-2017182437-A1 QUANTIFICATION OF AN INTERACTION BETWEEN A RAS PROTEIN AND A RAF PROTEIN UNIVERSITÄT INNSBRUCK (AT) 2017-10-26 — — WO disclosed
US-20160281129-A1 LUMINESCENT SUBSTRATE FOR USE IN ARTIFICIAL BIOLUMINESCENT ENZYME NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY (JP) 2016-09-29 — — US disclosed
US-20160281129-A1 LUMINESCENT SUBSTRATE FOR USE IN ARTIFICIAL BIOLUMINESCENT ENZYME NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY (JP) 2016-09-29 — — US disclosed
US-20100105090-A1 SECRETED LUCIFERASE MLUC7 AND USE THEREOF BAYER HEALTHCARE AG (DE) 2010-04-29 — — US disclosed
US-20100105090-A1 SECRETED LUCIFERASE MLUC7 AND USE THEREOF BAYER HEALTHCARE AG (DE) 2010-04-29 — — US disclosed
US-7396655-B2 Method for enhancing activity of luciferase with fluorescence activity CHISSO CORPORATION (JP) 2008-07-08 — — US disclosed
US-7396655-B2 Method for enhancing activity of luciferase with fluorescence activity CHISSO CORPORATION (JP) 2008-07-08 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11691976-B2 Coelenterazine analogues GLB1, SI, TCF7L2 ABCB1 1116/4885ADORA3 3089/4885PTGDR2 3614/4885
US-20160281129-A1 LUMINESCENT SUBSTRATE FOR USE IN ARTIFICIAL BIOLUMINESCENT ENZYME GALC, GUSB, GLB1 ABCB1 3205/4885ADORA3 1043/4885PTGDR2 4302/4885
US-20100105090-A1 SECRETED LUCIFERASE MLUC7 AND USE THEREOF LUC7L2, MRPL37, TCF7 ABCB1 3223/4885ADORA3 3953/4885PTGDR2 4619/4885
US-20240239803-A1 SYNTHESIS OF COELENTERAZINE ACHE, UROD, DDT ABCB1 1652/4885ADORA3 1581/4885PTGDR2 1550/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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