SCHEMBL1343673

SCHEMBL1343673

Cc1ccc(Cl)c(Cl)c1C#N

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 3/20 0.39
L3MBTL1 Q9Y468 2/20 0.39
USP2 O75604 1/20 0.39
ALDH1A1 P00352 5/20 0.39
MEN1 O00255 4/20 0.39
KMT2A Q03164 4/20 0.39
MAPT P10636 3/20 0.39
HPGD P15428 3/20 0.39
TP53 P04637 1/20 0.39
CYP3A4 P08684 1/20 0.39
MAPK1 P28482 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
CYP1A2 P05177 1/20 0.37
CYP2C19 P33261 1/20 0.37
TSHR P16473 3/20 0.36
HTT P42858 2/20 0.36
GLA P06280 1/20 0.36
KDM4E B2RXH2 8/20 0.35
ALOX15 P16050 1/20 0.35
APOBEC3G Q9HC16 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3976816 0.82 L3MBTL1 (0.39) HSD17B10L3MBTL1USP2ALDH1A1MEN1
SCHEMBL10120883 0.82 HSD17B10 (0.39) HSD17B10L3MBTL1USP2ALDH1A1MEN1
SCHEMBL4422003 0.80 ALDH1A1 (0.46) L3MBTL1ALDH1A1MEN1KMT2AMAPT
SCHEMBL5163774 0.80 AR (0.46) ALDH1A1MEN1KMT2AMAPTHPGD
SCHEMBL6734488 0.78 CYP3A4 (0.39) HSD17B10L3MBTL1USP2ALDH1A1MEN1
SCHEMBL23846799 0.78 L3MBTL1 (0.50) HSD17B10L3MBTL1USP2ALDH1A1MEN1
SCHEMBL10991120 0.78 CYP3A4 (0.39) HSD17B10L3MBTL1USP2ALDH1A1MEN1
SCHEMBL8112763 0.78 ALDH1A1 (0.36) HSD17B10L3MBTL1USP2ALDH1A1MEN1
SCHEMBL3579555 0.77 L3MBTL1 (0.39) HSD17B10L3MBTL1USP2ALDH1A1MEN1
SCHEMBL7975208 0.77 CYP1A2 (0.46) HSD17B10L3MBTL1ALDH1A1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113698593-A Composite material and preparation method thereof 电子科技大学 2021-11-26 CN claimed
US-5136110-A Reacting phenol with suitable aromatic halogen compounds; recovering triaryl bisphenols THE DOW CHEMICAL COMPANY (US) 1992-08-04 US claimed
CN-113698593-A Composite material and preparation method thereof 电子科技大学 2021-11-26 CN disclosed
US-11040954-B1 CXCR3 receptor agonists RECEPTOS LLC (US) 2021-06-22 US disclosed
US-20190345133-A1 CXCR3 RECEPTOR AGONISTS RECEPTOS LLC 2019-11-14 US disclosed
US-8062429-B2 Methods of cleaning semiconductor devices at the back end of line using amidoxime compositions EKC TECHNOLOGY, INC. (US) 2011-11-22 US disclosed
US-20100227870-A1 Novel Compounds GLAXO GROUP LIMITED (GB) 2010-09-09 US disclosed
US-20100043823-A1 METHODS OF CLEANING SEMICONDUCTOR DEVICES AT THE BACK END OF LINE USING AMIDOXIME COMOSITIONS U.S. BANK TRUST COMPANY, NATIONAL ASSOCIATION, AS NOTES COLLATERAL AGENT 2010-02-25 US disclosed
US-20090137191-A1 COPPER CMP POLISHING PAD CLEANING COMPOSITION COMPRISING OF AMIDOXIME COMPOUNDS EKC TECHNOLOGY, INC. 2009-05-28 US disclosed
US-20090133716-A1 METHODS OF POST CHEMICAL MECHANICAL POLISHING AND WAFER CLEANING USING AMIDOXIME COMPOSITIONS EKC TECHNOLOGY, INC. 2009-05-28 US disclosed
WO-2008152089-A1 NOVEL COMPOUNDS GLAXO GROUP LIMITED (GB) 2008-12-18 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100227870-A1 Novel Compounds GRM5, GRIK5, GRM1 HSD17B10 2612/4885L3MBTL1 4617/4885USP2 4202/4885
US-11040954-B1 CXCR3 receptor agonists CXCR3, CXCR1, CCR7 HSD17B10 2613/4885L3MBTL1 2670/4885USP2 4596/4885
US-20190345133-A1 CXCR3 RECEPTOR AGONISTS CXCR3, CXCR1, CCR7 HSD17B10 2613/4885L3MBTL1 2670/4885USP2 4596/4885
US-20090137191-A1 COPPER CMP POLISHING PAD CLEANING COMPOSITION COMPRISING OF AMIDOXIME COMPOUNDS PADI2, PADI4, PADI3 HSD17B10 3935/4885L3MBTL1 4670/4885USP2 250/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.