Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C3AR1 | Q16581 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | NPY4R | P50391 | 4/20 | 0.35 |
| ▸ | NPY1R | P25929 | 2/20 | 0.35 |
| ▸ | GGT1 | P19440 | 1/20 | 0.35 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.34 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.34 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.34 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.34 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | OTC | P00480 | 1/20 | 0.33 |
| ▸ | NPY2R | P49146 | 1/20 | 0.32 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20798171 | 0.92 | C3AR1 (0.37) | C3AR1MEN1GAAKMT2ATSHR | |
| SCHEMBL20797913 | 0.92 | C3AR1 (0.37) | C3AR1MEN1GAAKMT2ATSHR | |
| SCHEMBL10727007 | 0.90 | NPY4R (0.38) | TSHRNPY4RNPY1RALDH1A1NPY2R | |
| SCHEMBL1345056 | 0.89 | NPY4R (0.41) | MEN1GAAKMT2ATSHRNPY4R | |
| SCHEMBL144726 | 0.85 | GGT1 (0.40) | C3AR1MEN1GAAKMT2ANPY4R | |
| SCHEMBL350198 | 0.84 | NOD1 (0.41) | C3AR1MEN1GAAKMT2AGGT1 | |
| SCHEMBL350197 | 0.84 | NOD1 (0.41) | C3AR1MEN1GAAKMT2AGGT1 | |
| SCHEMBL14848982 | 0.83 | C3AR1 (0.39) | C3AR1MEN1GAAKMT2ANPY4R | |
| SCHEMBL1149706 | 0.83 | NOD1 (0.43) | C3AR1MEN1GAAKMT2ANPY4R | |
| SCHEMBL6429710 | 0.82 | NOD1 (0.49) | C3AR1GGT1FOLH1NOD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828109-B1 | GUANIDINE DERIVATIVES AS INHIBITORS OF DDAH | UCL BUSINESS PLC (GB) | 2013-06-05 | — | — | EP | claimed |
| US-8063104-B2 | Guanidine derivatives as inhibitors of DDAH | UCL BUSINESS PLC (GB) | 2011-11-22 | — | — | US | claimed |
| EP-2355807-B1 | INHIBITORS OF DIMETHYLARGININE DIMETHYLAMINOHYDROLASE | UNIV KIEL CHRISTIAN ALBRECHTS (DE) | 2018-08-22 | — | — | EP | disclosed |
| US-8921421-B2 | Inhibitors of dimethylarginine dimethylaminohydrolase | CHRISTIAN-ALBRECHTS-UNIVERSITAET ZU KIEL (DE) | 2014-12-30 | — | — | US | disclosed |
| EP-1828109-B1 | GUANIDINE DERIVATIVES AS INHIBITORS OF DDAH | UCL BUSINESS PLC (GB) | 2013-06-05 | — | — | EP | disclosed |
| US-20110294878-A1 | Inhibitors of Dimethylarginine Dimethylaminohydrolase | CHRISTIAN-ALBRECHTS-UNIVERSITAET ZU KIEL (DE) | 2011-12-01 | — | — | US | disclosed |
| US-8063104-B2 | Guanidine derivatives as inhibitors of DDAH | UCL BUSINESS PLC (GB) | 2011-11-22 | — | — | US | disclosed |
| EP-2355807-A1 | INHIBITORS OF DIMETHYLARGININE DIMETHYLAMINOHYDROLASE | Christian-Albrechts-Universität zu Kiel (DE) | 2011-08-17 | — | — | EP | disclosed |
| WO-2010066239-A1 | INHIBITORS OF DIMETHYLARGININE DIMETHYLAMINOHYDROLASE | CHRISTIAN-ALBRECHTS-UNIVERSITÄT ZU KIEL (DE) | 2010-06-17 | — | — | WO | disclosed |
| US-20090069331-A1 | GUANIDINE DERIVATIVES AS INHIBITORS OF DDAH | UCL Biomedica PLC c/o Finance Division University College of London (GB) | 2009-03-12 | — | — | US | disclosed |
| EP-1828109-A2 | GUANIDINE DERIVATIVES AS INHIBITORS OF DDAH | UCL Business PLC (GB) | 2007-09-05 | — | — | EP | disclosed |
| WO-2006051314-A2 | GUANIDINE DERIVATIVES AS INHIBITORS OF DDAH | UCL BUSINESS PLC (GB) | 2006-05-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110294878-A1 | Inhibitors of Dimethylarginine Dimethylaminohydrolase | DDAH1, PADI1, DOHH | C3AR1 606/4885MEN1 2354/4885GAA 2028/4885 |
| US-20090069331-A1 | GUANIDINE DERIVATIVES AS INHIBITORS OF DDAH | DDAH1, DOHH, IMPDH1 | C3AR1 2610/4885MEN1 2705/4885GAA 47/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.