Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | ACHE | P22303 | 2/20 | 0.35 |
| ▸ | TPMT | P51580 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.32 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.32 |
| ▸ | C1S | P09871 | 1/20 | 0.32 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.32 |
| ▸ | SELL | P14151 | 1/20 | 0.32 |
| ▸ | SELP | P16109 | 1/20 | 0.32 |
| ▸ | SELE | P16581 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | RAPGEF4 | Q8WZA2 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1451703 | 0.97 | ALDH1A1 (0.44) | ALDH1A1TSHRACHETPMTCA1 | |
| Lithium Ion SCHEMBL135924 | 0.93 | ALDH1A1 (0.42) | ALDH1A1TSHRACHETPMTCA1 | |
| SCHEMBL137999 | 0.93 | ALDH1A1 (0.42) | ALDH1A1TSHRACHETPMTCA1 | |
| Potassium Ion SCHEMBL134408 | 0.73 | ACHE (0.58) | ALDH1A1TSHRACHEMAPTCYP3A4 | |
| SCHEMBL1450779 | 0.73 | ACHE (0.58) | ALDH1A1TSHRACHEMAPTCYP3A4 | |
| SCHEMBL341533 | 0.73 | ALDH1A1 (0.67) | ALDH1A1TSHRACHETPMTPRSS1 | |
| SCHEMBL26115 | 0.73 | — | — | |
| Lithium Ion SCHEMBL136597 | 0.71 | ACHE (0.55) | ALDH1A1TSHRACHEMAPTCYP3A4 | |
| SCHEMBL137227 | 0.71 | ACHE (0.55) | ALDH1A1TSHRACHEMAPTCYP3A4 | |
| SCHEMBL23202758 | 0.69 | ALDH1A1 (0.61) | ALDH1A1TSHRACHETPMTPRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 229 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150119848-A1 | METHOD AND DEVICE FOR DETECTION OF BIOAVAILABLE DRUG CONCENTRATION | THE GOVERNMENT OF THE UNITED STATES, AS REPRESENTED BY THE SECRETARY OF THE ARMY | 2015-04-30 | — | — | US | claimed |
| US-8329833-B2 | Nano-linked metallocene catalyst compositions and their polymer products | CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) | 2012-12-11 | — | — | US | claimed |
| US-8143183-B2 | Nano-linked metallocene catalyst compositions and their polymer products | CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) | 2012-03-27 | — | — | US | claimed |
| US-20120058886-A1 | Nano-Linked Metallocene Catalyst Compositions and Their Polymer Products | CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) | 2012-03-08 | — | — | US | claimed |
| US-8012900-B2 | Nano-linked metallocene catalyst compositions and their polymer products | CHEVRON PHILLIPS CHEMICAL COMPANY, L.P. (US) | 2011-09-06 | — | — | US | claimed |
| EP-1711543-B1 | CATALYST COMPOSITIONS AND POLYOLEFINS FOR EXTRUSION COATING APPLICATIONS | CHEVRON PHILLIPS CHEMICAL CO (US) | 2011-08-24 | — | — | EP | claimed |
| US-20110059840-A1 | NANO-LINKED METALLOCENE CATALYST COMPOSITIONS AND THEIR POLYMER PRODUCTS | CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) | 2011-03-10 | — | — | US | claimed |
| US-20090170690-A1 | NANO-LINKED METALLOCENE CATALYST COMPOSITIONS AND THEIR POLYMER PRODUCTS | CHEVRON PHILLIPS CHEMICAL COMPANY (US) | 2009-07-02 | — | — | US | claimed |
| US-20070179044-A1 | Polymerization catalysts for producing high molecular weight polymers with low levels of long chain branching | CHEVRON PHILLIPS CHEMICAL COMPANY, L.P. | 2007-08-02 | — | — | US | claimed |
| US-7199073-B2 | Resins that yield low haze films and the process for their production | CHEVRON PHILLIPS CHEMICAL COMPANY, LP (US) | 2007-04-03 | — | — | US | claimed |
| US-6982306-B2 | Stannoxy-substituted metallocene catalysts for olefin and acetylene polymerization | CHEVRON PHILLIPS CHEMICAL COMPANY, L.P. (US) | 2006-01-03 | — | — | US | claimed |
| US-20050113245-A1 | STANNOXY-SUBSTITUTED METALLOCENE CATALYSTS FOR OLEFIN AND ACETYLENE POLYMERIZATION | CHEVRON PHILLIPS CHEMICAL COMPANY LP | 2005-05-26 | — | — | US | claimed |
| US-11998902-B2 | Processes for producing fluorided solid oxides and uses thereof in metallocene-based catalyst systems | CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) | 2024-06-04 | — | — | US | disclosed |
| US-11686722-B2 | Compositions and methods to detect molecules in a sample | INFUSENSE CORP. (US) | 2023-06-27 | — | — | US | disclosed |
| US-11208514-B2 | Silica-coated alumina activator-supports for metallocene catalyst compositions | CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) | 2021-12-28 | — | — | US | disclosed |
| US-11186665-B2 | Catalyst composition and method for preparing polyethylene | CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) | 2021-11-30 | — | — | US | disclosed |
| EP-0648786-A1 | Process for producing alpha-olefin polymer | Tosoh Corporation (JP) | 1995-04-19 | — | — | EP | disclosed |
| EP-0619326-A1 | Olefin polymerization catalyst and olefin polymerisation process | TOSOH CORPORATION (JP) | 1994-10-12 | — | — | EP | disclosed |
| EP-0612769-A1 | Process for producing ethylene alpha-olefin copolymer | TOSOH CORPORATION (JP) | 1994-08-31 | — | — | EP | disclosed |
| EP-0612768-A1 | Process for producing ethylene/alpha-olefin copolymer | TOSOH CORPORATION (JP) | 1994-08-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090170690-A1 | NANO-LINKED METALLOCENE CATALYST COMPOSITIONS AND THEIR POLYMER PRODUCTS | NCL, CPNE4, NDC1 | ALDH1A1 1618/4885TSHR 4839/4885ACHE 3363/4885 |
| US-11186665-B2 | Catalyst composition and method for preparing polyethylene | PCBP1, POF1B, PORCN | ALDH1A1 3310/4885TSHR 3786/4885ACHE 1447/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.